INT125525

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 2.72
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKDC) protein modification process (PRKDC) nucleus (PRKDC)
enzyme binding (PRKDC) DNA binding (PRKDC) transcription factor binding (PRKDC)
Anatomy Link Frequency
neurons 2
brain 2
neuronal 1
synapses 1
PRKDC (Homo sapiens)
Pain Link Frequency Relevance Heat
amygdala 290 97.32 Very High Very High Very High
Pyramidal cell 40 94.24 High High
nMDA receptor 125 91.04 High High
Kinase C 4 90.04 High High
agonist 19 87.04 High High
Pain 18 79.84 Quite High
withdrawal 45 72.80 Quite High
Inflammation 19 72.12 Quite High
adenocard 29 69.68 Quite High
cINOD 3 66.80 Quite High
Disease Link Frequency Relevance Heat
Syndrome 107 99.24 Very High Very High Very High
Infection 8 98.12 Very High Very High Very High
Apoptosis 15 95.40 Very High Very High Very High
Increased Venous Pressure Under Development 12 90.40 High High
Hyperplasia 1 88.00 High High
Prostate Cancer 4 78.96 Quite High
Autism 1570 78.92 Quite High
INFLAMMATION 25 72.12 Quite High
Cognitive Disorder 215 68.08 Quite High
Targeted Disruption 39 63.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis with primary cortical neurons expressing mutant Htt showed that protein levels of Ku70 and Ku80 but not of DNA–PKcs transiently increased at day 1, decreased from day 1 to day 6 after infection, and returned to the initial level (Fig. 6, A–C).
Positive_regulation (increased) of DNA-PKcs in neurons associated with infection
1) Confidence 0.45 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.10 Pain Relevance 0
One key nuclear function of EGFR is phosphorylation and activation of DNA-dependent protein kinase (DNA-PK), an enzyme that is involved in repair of breaks in double-stranded DNA caused by radiation and chemotherapy.18,19 EGFR localizing to the nuclear compartment can also enter transcriptional complexes and bind to the promoter region of cyclin D1 to promote cell cycle progression and increase cellular proliferation.20 EGFR inhibition delays the repair of chemotherapy-induced DNA damage via modulation of DNA repair genes such as XRCC1 and ERCC1, which could explain some of the increased activity of cisplatin when combined with EGFR inhibitors such as cetuximab.21–23
Positive_regulation (activation) of DNA-dependent protein kinase associated with hyperplasia
2) Confidence 0.10 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921255 Disease Relevance 0.24 Pain Relevance 0
Expression of constitutively active PKCs induced an increase in NF-kappa B transcriptional activity and NAG-1 protein levels in LNCaP cells.
Positive_regulation (Expression) of PKCs
3) Confidence 0.08 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15757899 Disease Relevance 0.44 Pain Relevance 0.26
Thus, downstream effects of conventional, Ca2+-activated PKCs include a direct phosphorylation of p47phox, which leads to membrane translocation of cytosolic components (Fig. 1).


Positive_regulation (activated) of PKCs
4) Confidence 0.03 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.06 Pain Relevance 0.07
At least 12 different PKC isoforms have been characterized so far, and these can be grouped into the following three subgroups: conventional PKCs (?
Positive_regulation (grouped) of PKCs
5) Confidence 0.03 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
This catalyzes the conversion of GTP to cGMP, which increases the activity of a series of cGMP-dependent protein kinases (PKCs), particularly the I?
Positive_regulation (increases) of PKCs
6) Confidence 0.03 Published 2010 Journal International Journal of Vascular Medicine Section Body Doc Link PMC3003984 Disease Relevance 0.16 Pain Relevance 0.07
The amygdala contains relatively higher numbers of inhibitory interneurons than in the neocortex and reducing inhibition may be more effective in causing hyper-functionality than hyper-connecting through glutamatergic synapses.
Positive_regulation (causing) of hyper-functionality in synapses associated with amygdala
7) Confidence 0.01 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3010743 Disease Relevance 0.37 Pain Relevance 0.36
In the brain, this common molecular syndrome is proposed to have a dual effect of causing hyper-reactivity and hyper-plasticity of microcircuits to produce hyper-functionality (Figure 5).
Positive_regulation (causing) of hyper-plasticity in brain associated with syndrome
8) Confidence 0.01 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3010743 Disease Relevance 0.56 Pain Relevance 0.03
In summary, the neuronal network response in VPA-treated offspring is greatly amplified, resulting in hyper-reactivity to network stimulation as a common denominator between several distinct brain regions (Figure 1).
Positive_regulation (resulting) of hyper-reactivity in neuronal
9) Confidence 0.01 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3010743 Disease Relevance 0.15 Pain Relevance 0.21
In the brain, this common molecular syndrome is proposed to have a dual effect of causing hyper-reactivity and hyper-plasticity of microcircuits to produce hyper-functionality (Figure 5).
Positive_regulation (causing) of hyper-reactivity in brain associated with syndrome
10) Confidence 0.01 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3010743 Disease Relevance 0.51 Pain Relevance 0.03
Several potential mechanisms can be excluded to underlie this hyper-reactivity, such as more excitable neurons or stronger excitatory synaptic connections, or changes in morphology.
Positive_regulation (underlie) of hyper-reactivity in neurons
11) Confidence 0.01 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3010743 Disease Relevance 0.14 Pain Relevance 0.19

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