INT125534

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 9
Speculated 2
Reported most in Body
Documents 31
Total Number 35
Disease Relevance 13.88
Pain Relevance 5.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 2
medulla 1
liver 1
spinal cord 1
brain 1
Tg(CAG-EGFP)D4Nagy (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 34 99.10 Very High Very High Very High
mu opioid receptor 12 99.00 Very High Very High Very High
Nav1.7 5 98.92 Very High Very High Very High
medulla 35 98.80 Very High Very High Very High
Inflammation 291 98.44 Very High Very High Very High
gABA 7 98.44 Very High Very High Very High
Opioid 1 97.40 Very High Very High Very High
Pain 49 97.08 Very High Very High Very High
midbrain 18 96.96 Very High Very High Very High
GABAergic 14 96.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 49 100.00 Very High Very High Very High
Targeted Disruption 266 99.90 Very High Very High Very High
Cytomegalovirus Infection 52 99.80 Very High Very High Very High
Cold Sores 408 99.66 Very High Very High Very High
Age-related Macular Degeneration 28 99.50 Very High Very High Very High
Nociception 34 98.92 Very High Very High Very High
Multiple Sclerosis 399 98.84 Very High Very High Very High
INFLAMMATION 314 98.44 Very High Very High Very High
Stress 27 97.44 Very High Very High Very High
Skin Cancer 8 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we defined experimental systems to visualize and quantify down-regulation of a constitutively expressed eGFP reporter gene, and the localization of siRNAs in subcutaneous B16-F10 melanoma tumors using fluorescence imaging.
Regulation (regulation) of eGFP in B16-F10 associated with cancer, skin cancer and imagery
1) Confidence 0.39 Published 2008 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Body Doc Link PMC2737239 Disease Relevance 0.37 Pain Relevance 0.09
Single microinjection of vector expressing EGFP under a CMV promoter control (LV-EGFP) allowed vector diffusion along a rostro-caudal axis but strictly restricted to the grey matter of the ipsilateral dorsal spinal cord.
Regulation (control) of LV-EGFP in spinal cord associated with cytomegalovirus infection and spinal cord
2) Confidence 0.22 Published 2008 Journal J. Neurosci. Methods Section Abstract Doc Link 17949823 Disease Relevance 0.49 Pain Relevance 0.43
Fluorescent microscopy at 48 h post-transduction revealed that transduction with HSV-U6shLacZ had no effect on GFP expression levels, whereas transduction with HSV-U6shGFP resulted in almost complete inhibition of GFP expression (Figure 4).
Neg (no) Regulation (effect) of GFP associated with cold sores
3) Confidence 0.22 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 1.61 Pain Relevance 0.08
Fluorescent microscopy at 48hrs post-transduction revealed that transduction with HSV-U6shLacZ had no effect on GFP expression levels, whereas transduction with HSV-U6shGFP resulted in a dramatic reduction in the levels of GFP compared to control groups (magnification 10×).


Neg (no) Regulation (effect) of GFP associated with cold sores
4) Confidence 0.22 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 1.61 Pain Relevance 0.16
We also show that the levels of GFP are not affected by expression of shRNA targeting lacZ, and vice versa, thus excluding any potential non-specific effects induced by the HSV vector backbone.
Neg (not) Regulation (affected) of GFP associated with cold sores
5) Confidence 0.22 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 0.28 Pain Relevance 0.22
We observed no difference in GFP?
Neg (no) Regulation (difference) of GFP
6) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.06 Pain Relevance 0
Effect of aging on GFP?
Regulation (Effect) of GFP associated with aging
7) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.33 Pain Relevance 0.06
EGFP immunoreactivity was absent in the mock injected controls and showed modest labeling of photoreceptors and RPE cells in the naked plasmid injected samples.
Regulation (immunoreactivity) of EGFP in photoreceptors
8) Confidence 0.20 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762345 Disease Relevance 0 Pain Relevance 0
Furthermore, in the matrix compartment of the neostriatum of the three lines, intense GFP immunoreactivity was densely distributed in the neuronal cell bodies and neuropil, and matrix neurons displayed > 94% co-localization for GFP and PPE immunoreactivities.
Regulation (immunoreactivities) of GFP in neuronal
9) Confidence 0.20 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 19046386 Disease Relevance 0.24 Pain Relevance 0.27
A similar reciprocal organization of PPE and MOR expression was also suggested in the ventral striatum, because GFP immunoreactivity was weaker in intensely MOR-immunopositive regions than in the surrounding MOR-negative regions.
Regulation (immunoreactivity) of GFP in striatum associated with mu opioid receptor
10) Confidence 0.20 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 19046386 Disease Relevance 0.19 Pain Relevance 0.38
These results further confirm that most patrolling GFP+ cells are CD1d-reactive T cells and indicate that these patrolling liver NKT cells undergo rapid arrest upon activation via TCRs.


Regulation (patrolling) of GFP in liver
11) Confidence 0.19 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0 Pain Relevance 0
In particular, mononuclear cells in the perivascular region of the brain displayed a range of RFP/GFP ratios consistent with those in the blood (Figures 2 5, and 6).
Regulation (range) of GFP in brain
12) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.26 Pain Relevance 0.06
Ly6Clo cells were clearly brighter than Ly6Chi cells, which had a wider range of GFP intensities.
Regulation (range) of GFP
13) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.15 Pain Relevance 0.04
To verify the sensitivity of the GFP?
Regulation (sensitivity) of GFP
14) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.19 Pain Relevance 0.07
In this report, we describe the development and characterization of this model, and determine that aging alone does not alter neuronal GFP?
Neg (not) Spec (determine) Regulation (alter) of GFP in neuronal associated with aging
15) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.57 Pain Relevance 0
No GFP immunoreactivity was found in the ganglia of transgenic mice (Figure 2e), demonstrating that WGA was not produced in the ganglion, but migrated to the ganglion cells by crossing synapses.
Neg (No) Regulation (immunoreactivity) of GFP in ganglia associated with ganglion cysts and targeted disruption
16) Confidence 0.11 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.94 Pain Relevance 0
No GFP immunoreactivity was found in any part of the medulla.
Neg (No) Regulation (immunoreactivity) of GFP in medulla associated with medulla
17) Confidence 0.11 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.27 Pain Relevance 0.23
Interestingly, the absence of CX3CR1 in the Ccr2RFP/+Cx3cr1GFP/GFP mice had little or no effect on the RFP/GFP profile or the number of recruited cells.
Neg (little) Regulation (effect) of GFP
18) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.97 Pain Relevance 0.21
Whole-cell recordings were obtained from layer 2/3 pyramidal neurons, which were either GFP-positive (NR1 KO) or GFP-negative (control).
Regulation (control) of GFP-negative in pyramidal neurons associated with targeted disruption and pyramidal cell
19) Confidence 0.08 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0.10 Pain Relevance 0.08
Axon degeneration was relatively infrequent (affecting less than 5% of GFP-positive axons).
Regulation (affecting) of GFP
20) Confidence 0.08 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1180514 Disease Relevance 0 Pain Relevance 0.04

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