INT125541

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.14
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP3A4) oxidoreductase activity (CYP3A4) endoplasmic reticulum (CYP3A4)
enzyme binding (CYP3A4) lipid metabolic process (CYP3A4) cytoplasm (CYP3A4)
Anatomy Link Frequency
blood 1
liver 1
hepatocytes 1
CYP3A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
monoamine 2 100.00 Very High Very High Very High
antagonist 21 95.16 Very High Very High Very High
fluoxetine 2 94.72 High High
Bile 123 91.24 High High
Versed 9 85.76 High High
lidocaine 3 81.52 Quite High
agonist 28 81.20 Quite High
Migraine 2 75.00 Quite High
Serotonin 1 75.00 Quite High
Potency 1 36.88 Quite Low
Disease Link Frequency Relevance Heat
Cirrhosis 76 99.32 Very High Very High Very High
Cancer 56 95.08 Very High Very High Very High
Gallstones 38 92.32 High High
Injury 10 91.68 High High
Hepatocellular Cancer 2 75.28 Quite High
Renal Disease 2 75.00 Quite High
Headache 2 75.00 Quite High
Apoptosis 15 74.80 Quite High
Targeted Disruption 51 73.92 Quite High
Hypoalbuminemia 6 63.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Steroid and xenobiotic receptor (SXR) or human pregnane X receptor (hPXR) dimerizes with retinoid X receptor (RXR) and regulates the transcription of genes encoding xenobiotic-metabolizing enzymes such as CYP3A4.
Transcription (transcription) of CYP3A4
1) Confidence 0.69 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16632523 Disease Relevance 0.15 Pain Relevance 0
The HepG2-GS-3A4 expressed a higher amount of CYP3A4 protein and mRNA than control.
Transcription (expressed) of CYP3A4
2) Confidence 0.68 Published 2008 Journal Xenobiotica Section Abstract Doc Link 18846481 Disease Relevance 0 Pain Relevance 0.08
Almotriptan clearance was reduced, to a modest degree, by moclobemide and verapamil, which was consistent with the contribution of monoamine oxidase-A and CYP3A4 to the metabolic clearance of almotriptan.
Transcription (contribution) of CYP3A4 associated with monoamine
3) Confidence 0.67 Published 2005 Journal Clin Pharmacokinet Section Abstract Doc Link 15762767 Disease Relevance 0.29 Pain Relevance 0.48
These results reflected possible reduction in the activity of CYP3A4 in patients with chronic liver cirrhosis to form 6 ?
Transcription (activity) of CYP3A4 in liver associated with cirrhosis
4) Confidence 0.63 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716776 Disease Relevance 0.34 Pain Relevance 0
A prospective study is suggested on a large number of Egyptian healthy controls and patients with liver cirrhosis to study the correlation between CYP3A4 mRNA titer in blood and the urinary ratio of 6 ?
Transcription (titer) of CYP3A4 in blood associated with cirrhosis
5) Confidence 0.63 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716776 Disease Relevance 0.66 Pain Relevance 0
SXR can also directly regulate SHP expression [Frank et al., 2005] and FXR regulates CYP3A4 transcription through two functional FXR response elements in the promoter of CYP3A4 [Goodwin et al., 1999].
Transcription (transcription) of CYP3A4
6) Confidence 0.24 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.12 Pain Relevance 0.26
SFN efficiently inhibits SXR-mediated transcription of the CYP3A4 gene in a concentration-dependent manner.
Transcription (transcription) of CYP3A4
7) Confidence 0.18 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.26 Pain Relevance 0.13
Interestingly, it has also been reported that SFN downregulated CYP3A4 transcription and enzymatic activity in cultured human hepatocytes, suggesting another mechanism that could also contribute to its anti-cancer effects [Maheo et al., 1997].
Transcription (transcription) of CYP3A4 in hepatocytes associated with cancer
8) Confidence 0.18 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.31 Pain Relevance 0.07

General Comments

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