INT12555

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Context Info
Confidence 0.39
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 17
Disease Relevance 3.78
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (ADRB1) plasma membrane (ADRB1) nucleus (ADRB1)
cytoplasm (ADRB1) signal transducer activity (ADRB1)
Anatomy Link Frequency
platelet 2
blood 1
PMN 1
ADRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 5 99.76 Very High Very High Very High
depression 3 99.52 Very High Very High Very High
Clonidine 6 98.12 Very High Very High Very High
local anesthetic 1 89.92 High High
antagonist 3 82.88 Quite High
Potency 1 81.68 Quite High
ischemia 1 77.20 Quite High
antidepressant 2 75.00 Quite High
cytokine 22 68.64 Quite High
tricyclic antidepressant 2 68.56 Quite High
Disease Link Frequency Relevance Heat
Hypertension 8 99.86 Very High Very High Very High
Depression 4 99.52 Very High Very High Very High
Malaria 453 98.72 Very High Very High Very High
Hypotension 5 98.66 Very High Very High Very High
Toxicity 15 98.64 Very High Very High Very High
Cardiovascular Disease 5 94.08 High High
Parasitemia 99 91.60 High High
Diabetes Mellitus 8 87.16 High High
Heart Rate Under Development 2 83.68 Quite High
Coronary Artery Disease 3 80.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specific binding of 3H-yohimbine to the platelet adrenoreceptor is not altered in endogenously depressed patients.
adrenoreceptor Binding (binding) of in platelet
1) Confidence 0.39 Published 1983 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 6310693 Disease Relevance 0.36 Pain Relevance 0.30
This portion of the molecule also appears to account for bevantolol's in vitro binding affinity at alpha-adrenoceptor sites; the in vivo significance of which remains unclear.
adrenoceptor Binding (affinity) of
2) Confidence 0.32 Published 1986 Journal Angiology Section Abstract Doc Link 2871786 Disease Relevance 0.33 Pain Relevance 0.17
The blood pressure lowering effects of CS-905 was most potent in DOCA-salt hypertensive rats, followed by SHR, RHR and normotensive rats, in this order.
RHR Binding (followed) of in blood associated with hypertension and hypotension
3) Confidence 0.32 Published 1989 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2810942 Disease Relevance 0.45 Pain Relevance 0
Beta adrenergic receptors ADRB1 and ADRB2
ADRB1 Binding (receptors) of
4) Confidence 0.25 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.23 Pain Relevance 0.11
The interaction of berberine with human platelet alpha 2 adrenoceptor was investigated in this study.
adrenoceptor Binding (interaction) of in platelet
5) Confidence 0.24 Published 1991 Journal Life Sci. Section Abstract Doc Link 1649363 Disease Relevance 0.09 Pain Relevance 0.36
The use of a flow cytometric phagocytosis assay in association with ADRB readouts could help to establish a clearer relationship [50].
ADRB Binding (association) of
6) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.12 Pain Relevance 0
(iii) Since the toxicity of ROS generated by PMN is postulated to be an important factor in ADRB association with protection, the inhibitory effects of ADRB assay supernatants on P. falciparum cultures should be evaluated, and the putative implication of particular ROS determined using reversible inhibitors such as histidine, tryptophan, superoxide dismutase and/or catalase, to indicate which oxygen radicals, if any, are involved [49].
ADRB Binding (association) of associated with toxicity
7) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.16 Pain Relevance 0.03
RHR were both significantly associated with fasting insulin (??
RHR Binding (associated) of
8) Confidence 0.10 Published 2008 Journal Diabetologia Section Abstract Doc Link PMC2491413 Disease Relevance 0.34 Pain Relevance 0
This association between ADRB index and morbidity was most striking for the most susceptible 2–14 year olds.
ADRB Binding (association) of
9) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.14 Pain Relevance 0
120.4 vs 120.6) indicating that the risk of malaria attack was nearly 1.8-fold higher overall for individuals with ADRB index <250 than for those with ADRB index ?
ADRB Binding (index) of associated with malaria
10) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.16 Pain Relevance 0
The most important finding was that PMN ADRB activity was correlated with acquired clinical protection from malaria in both high and low transmission areas (P?
PMN ADRB Binding (activity) of in PMN associated with malaria
11) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2845614 Disease Relevance 0.43 Pain Relevance 0
ADRB indexes determined for the S1 sample in the three experiments shown in Figure 3 were 1183, 1072 and 1126, yielding a mean of 1127+/?
ADRB Binding (indexes) of
12) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0 Pain Relevance 0
Within each age group, individuals with a serum ADRB index ?
ADRB Binding (index) of
13) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.14 Pain Relevance 0
ADRB index and age were still significantly associated with immune status for each model.
ADRB Binding (associated) of
14) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.14 Pain Relevance 0
After multivariate analysis, three alternative models were proposed using: (i) continuously decreasing ADRB index (RR?
ADRB Binding (index) of
15) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.15 Pain Relevance 0
Following multivariate analysis described in Materials and Methods, two alternative models were proposed: (i) using continuously decreasing ADRB index (RR?
ADRB Binding (index) of
16) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.35 Pain Relevance 0
120.4 vs 120.6) indicating that the risk of malaria attack was nearly 1.8-fold higher overall for individuals with ADRB index <250 than for those with ADRB index ?
ADRB Binding (index) of associated with malaria
17) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.17 Pain Relevance 0

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