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Context Info
Confidence 0.02
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0.13

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mitochondrion (Cyp2e1) endoplasmic reticulum (Cyp2e1) enzyme binding (Cyp2e1)
cytoplasm (FGFR1) cytosol (FGFR1) extracellular region (FGFR1)
FGFR1 (Homo sapiens)
Cyp2e1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 4 78.84 Quite High
Paracetamol 1 67.84 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 1 74.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that SAM interacts with cytochrome P450s, especially CYP2E1, and inhibits the catalytic activity of CYP2E1 in a reversible and non competitive manner.
SAM Binding (interacts) of CYP2E1
1) Confidence 0.02 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15763544 Disease Relevance 0.07 Pain Relevance 0.13

General Comments

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