INT125560

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.35
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nr1i3) cytoskeleton (Nr1i3) nucleus (Nr1i3)
DNA binding (Nr1i3) cytoplasm (Nr1i3)
Anatomy Link Frequency
parenchymal cells 2
CAR 1
Nr1i3 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 4 64.24 Quite High
Paracetamol 6 46.56 Quite Low
addiction 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Embryonic Lethality 2 93.08 High High
Hepatomegaly 2 84.00 Quite High
Paralysis 2 47.76 Quite Low
Repression 2 47.00 Quite Low
Hepatotoxicity 6 44.80 Quite Low
Targeted Disruption 4 41.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Targeted deletion of coactivator PBP gene in liver parenchymal cells (PBP(LIV-/-)) results in the near abrogation of the induction of PPARalpha and CAR (constitutive androstane receptor)-regulated genes in liver.
Positive_regulation (induction) of CAR in parenchymal cells
1) Confidence 0.40 Published 2007 Journal Gene Expr. Section Abstract Doc Link 17605299 Disease Relevance 0.17 Pain Relevance 0
Targeted deletion of coactivator PBP gene in liver parenchymal cells (PBP(LIV-/-)) results in the near abrogation of the induction of PPARalpha and CAR (constitutive androstane receptor)-regulated genes in liver.
Positive_regulation (induction) of constitutive androstane receptor in parenchymal cells
2) Confidence 0.34 Published 2007 Journal Gene Expr. Section Abstract Doc Link 17605299 Disease Relevance 0.18 Pain Relevance 0
Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor.
Positive_regulation (activating) of androstane receptor
3) Confidence 0.10 Published 2005 Journal Mol. Endocrinol. Section Title Doc Link 15764585 Disease Relevance 0 Pain Relevance 0.06
In this report, we demonstrate that ASC-2 also serves as a coactivator of the xenobiotic nuclear receptor constitutive androstane receptor (CAR).
Positive_regulation (coactivator) of androstane receptor in CAR
4) Confidence 0.10 Published 2005 Journal Mol. Endocrinol. Section Abstract Doc Link 15764585 Disease Relevance 0 Pain Relevance 0.05

General Comments

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