INT125567

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.46
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Casr) plasma membrane (Casr) nucleus (Ncoa6)
enzyme binding (Ncoa6) protein complex (Ncoa6) signal transducer activity (Casr)
Anatomy Link Frequency
CAR 2
Ncoa6 (Mus musculus)
Casr (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 4 92.56 High High
agonist 4 70.48 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 4 97.64 Very High Very High Very High
Hepatotoxicity 4 93.48 High High
Repression 2 84.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results strongly suggest that ASC-2 is a bona fide coactivator of the xenobiotic nuclear receptor CAR and mediate the specific xenobiotic response by CAR in vivo.
ASC-2 Positive_regulation (coactivator) of CAR in CAR
1) Confidence 0.52 Published 2005 Journal Mol. Endocrinol. Section Abstract Doc Link 15764585 Disease Relevance 0.46 Pain Relevance 0.25
In this report, we demonstrate that ASC-2 also serves as a coactivator of the xenobiotic nuclear receptor constitutive androstane receptor (CAR).
ASC-2 Positive_regulation (coactivator) of CAR in CAR
2) Confidence 0.52 Published 2005 Journal Mol. Endocrinol. Section Abstract Doc Link 15764585 Disease Relevance 0 Pain Relevance 0.05

General Comments

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