INT125568

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.13
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Casr) nucleus (Ncoa6) plasma membrane (Casr)
enzyme binding (Ncoa6) protein complex (Ncoa6) signal transducer activity (Casr)
Anatomy Link Frequency
CAR 3
Casr (Mus musculus)
Ncoa6 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 4 98.86 Very High Very High Very High
Paracetamol 6 74.48 Quite High
cytokine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 28 95.20 Very High Very High Very High
Apoptosis 18 91.08 High High
Repression 6 79.36 Quite High
Obesity 5 75.56 Quite High
Hepatotoxicity 5 72.72 Quite High
Cancer 7 41.32 Quite Low
Hyperplasia 1 39.80 Quite Low
Necrosis 1 15.84 Low Low
Wound Healing 15 5.00 Very Low Very Low Very Low
Breast Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondly, CAR specifically interacted with the first LXXLL motif of ASC-2, and these interactions were stimulated by CAR agonist 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and repressed by CAR inverse agonist androstanol, suggesting that this motif may mediate the interactions of ASC-2 and CAR in vivo.
CAR Binding (interacted) of ASC-2 in CAR associated with agonist
1) Confidence 0.50 Published 2005 Journal Mol. Endocrinol. Section Abstract Doc Link 15764585 Disease Relevance 0.16 Pain Relevance 0.15
Secondly, CAR specifically interacted with the first LXXLL motif of ASC-2, and these interactions were stimulated by CAR agonist 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and repressed by CAR inverse agonist androstanol, suggesting that this motif may mediate the interactions of ASC-2 and CAR in vivo.
CAR Binding (interactions) of ASC-2 in CAR associated with agonist
2) Confidence 0.37 Published 2005 Journal Mol. Endocrinol. Section Abstract Doc Link 15764585 Disease Relevance 0.33 Pain Relevance 0.23
NCoA6(ASC-2) had been earlier shown to interact with CAR and enhance the transcriptional activation by CAR in transfection assays [Choi et al., 2005].
CAR Binding (interact) of NCoA6 in CAR
3) Confidence 0.12 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.63 Pain Relevance 0.07

General Comments

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