INT125573

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 8.00
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CS) small molecule metabolic process (CS) carbohydrate metabolic process (CS)
Anatomy Link Frequency
Platelet 5
lung 5
A549 2
stomach 1
pole 1
CS (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 20 95.76 Very High Very High Very High
Morphine 5 90.76 High High
ischemia 1 86.76 High High
Buprenorphine 15 86.52 High High
Pain 33 84.32 Quite High
Fibrositis 58 72.84 Quite High
alcohol 5 67.28 Quite High
cINOD 19 66.56 Quite High
amygdala 13 62.96 Quite High
Nicotine 135 51.36 Quite High
Disease Link Frequency Relevance Heat
Stress 1036 99.52 Very High Very High Very High
Lung Cancer 705 99.12 Very High Very High Very High
Atrial Flutter 17 98.16 Very High Very High Very High
Malignant Neoplastic Disease 315 97.64 Very High Very High Very High
Frailty 14 96.64 Very High Very High Very High
Injury 52 96.60 Very High Very High Very High
Nicotine Addiction 451 95.40 Very High Very High Very High
Targeted Disruption 7 93.48 High High
Volume Depletion And Dehydration 5 92.80 High High
Body Weight 16 87.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although CS protein expression was reduced over the course of immobilization, this reduction was not statistically significant (Figure 2).
Gene_expression (expression) of CS protein
1) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.10 Pain Relevance 0
stomach, that of the Capn8CS/CS mice expressed a stable and active calpain 9, the mice were susceptible to ethanol-induced gastric injury.
Gene_expression (expressed) of CS in stomach associated with injury
2) Confidence 0.33 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2912385 Disease Relevance 0.53 Pain Relevance 0.16
In contrast, we provide evidence that CS actively suppresses the splicing of XBP1.
Gene_expression (suppresses) of CS
3) Confidence 0.29 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.68 Pain Relevance 0
We report here that CS exposure induces ER stress and triggers the UPR in both normal and malignant human lung cells.
Gene_expression (exposure) of CS in lung associated with stress and malignant neoplastic disease
4) Confidence 0.29 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.06 Pain Relevance 0
The impact of CS exposure on XBP1 splicing was assessed.
Gene_expression (exposure) of CS
5) Confidence 0.29 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.37 Pain Relevance 0
The distal pole of the CS catheter is positioned at 4 to 6 o’clock in the LAO position.
Gene_expression (position) of CS in pole
6) Confidence 0.27 Published 2006 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC1501100 Disease Relevance 0.67 Pain Relevance 0
CS as follows:(5)dCsdt=?
Gene_expression (follows) of CS
7) Confidence 0.27 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 0 Pain Relevance 0
Thus, these data indicate that the ability of CS to suppress XBP1 splicing is not cell or cigarette type specific but more likely due to a general property of CS exposure.
Gene_expression (exposure) of CS
8) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.08 Pain Relevance 0
Effect of CS exposure on the ATF6 branch of UPR in human lung cells
Gene_expression (exposure) of CS in lung
9) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.12 Pain Relevance 0
Effect of CS exposure on the IRE1 branch of UPR in normal human lung cells
Gene_expression (exposure) of CS in lung
10) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.48 Pain Relevance 0
Figures 1A and 1B also show that during the time period studied (0–4 hours after CS exposure) there were no significant changes in protein levels of total eIF2?
Gene_expression (exposure) of CS
11) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.16 Pain Relevance 0
Effect of CS exposure on the expression of BiP in human lung cells
Gene_expression (exposure) of CS in lung
12) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.29 Pain Relevance 0
Figure 10 shows that the thiol N-acetyl-L-cysteine (NAC), a potent free radical scavenging compound with antioxidant activity, can completely prevent CS-induced phosphorylation of eIF2?
Neg (prevent) Gene_expression (prevent) of CS
13) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.24 Pain Relevance 0
Two-Group Comparisons with Permutation Analysis for Differential Expression (PADE) was used to determine differential gene expression between CS-exposed and mock-exposed groups at each time point, each group consisting of multiple arrays.
Spec (determine) Gene_expression (expression) of CS
14) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0 Pain Relevance 0
Does this mean that the induced expression of these UPR-related proteins is not directly related to CS exposure or, alternatively, that their induction is a general convergent feature of lung cancers regardless of the provoking stimulus?
Gene_expression (exposure) of CS in lung associated with lung cancer
15) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.39 Pain Relevance 0
It is possible that one or more components of CS can attack the structure of the IRE1 transmembrane protein thereby disabling its ribonuclease function and subsequent splicing of the XBP1 mRNA to its transcriptionally active isoform.
Gene_expression (function) of CS
16) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.71 Pain Relevance 0
As previously observed for whole CS, there was no alteration in the total level of eIF2?
Gene_expression (observed) of CS
17) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.29 Pain Relevance 0.03
Thus, in order to assess the effect of CS on ATF6 cleavage we constructed a full length ATF6/pCMV6 expression plasmid and transfected it into A549 cells which were then exposed to CS.
Gene_expression (exposed) of CS in A549
18) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.08 Pain Relevance 0
Similarly, Figure 4 (Panel B) shows that treatment of ATF6-transfected A549 cells with CS also results in disappearance of ATF6 starting at 2 h post-CS exposure and continuing to at least 4 h post-exposure.
Gene_expression (exposure) of CS in A549
19) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.09 Pain Relevance 0
As stated previously, at the average response level, increased response to hit trials during the CS+ condition relative to the CS?
Gene_expression (condition) of CS
20) Confidence 0.12 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2953413 Disease Relevance 0 Pain Relevance 0.03

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