INT125588

Context Info Confidence 0.49 First Reported 2004 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 1.57 Pain Relevance 0.11

nucleus (Pcna) intracellular (Pcna) DNA binding (Pcna) transcription factor binding (Pcna) cytoplasm (Pcna)

Anatomy Link Frequency epithelium 2 Pcna (Mus musculus)

Pain Link Frequency Relevance Heat cINOD 1 78.24 cerebral cortex 27 59.00 Hippocampus 3 13.72 metalloproteinase 12 5.00 antagonist 9 5.00 ischemia 6 5.00 Pain 3 5.00 alcohol 3 5.00 Multiple sclerosis 3 5.00 ketamine 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 224 100.00 Sprains And Strains 2 98.84 Lung Cancer 4 90.00 Suicidal Behaviour 81 86.80 Adhesions 12 81.12 Neurodegenerative Disease 24 65.24 Death 51 40.52 Breast Cancer 1 25.20 Convulsion 3 14.08 Cancer 13 12.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Much more intense were the smoke-induced alterations of a variety of intermediate biomarkers, such as cytogenetic end points in pulmonary alveolar macrophages, bone marrow and peripheral blood erythrocytes; apoptosis, p53 oncoprotein, and proliferating cell nuclear antigen in the bronchial epithelium; bulky DNA adducts, 8-hydroxy-2-deoxyguanosine; multigene expression, and thiobarbituric acid-reactive aldehydes in whole lung and several other organs.

Positive_regulation (smoke-induced) of Gene_expression (expression) of proliferating cell nuclear antigen in epithelium associated with apoptosis

1) Confidence 0.49 Published 2005 Journal Exp. Lung Res. Section Abstract Doc Link 15765917 Disease Relevance 0.61 Pain Relevance 0.08

The induction of proliferation in a subset of bronchiolar cells and alveolar type II cells by Sox17 was associated with increased expression of several cyclin genes known to stimulate cell cycle progression.

Positive_regulation (increased) of Gene_expression (expression) of cyclin

2) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0

In contrast, estrogen and sFasL, individually and together, induced cyclin-A expression, suggesting activation of compensatory survival mechanisms.

Positive_regulation (induced) of Gene_expression (expression) of cyclin

3) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Abstract Doc Link PMC395829 Disease Relevance 0.53 Pain Relevance 0

Estrogen and sFasL separately and together induce expression of cyclin A.

Positive_regulation (induce) of Gene_expression (expression) of cyclin

4) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.27 Pain Relevance 0.03

Both estrogen and sFasL alone led to a statistically significant increase in the expression of cyclin-A compared with controls at 12 hours post-treatment.

Positive_regulation (increase) of Gene_expression (expression) of cyclin

5) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.16 Pain Relevance 0

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