INT125588

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.57
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pcna) intracellular (Pcna) DNA binding (Pcna)
transcription factor binding (Pcna) cytoplasm (Pcna)
Anatomy Link Frequency
epithelium 2
Pcna (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 1 78.24 Quite High
cerebral cortex 27 59.00 Quite High
Hippocampus 3 13.72 Low Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 224 100.00 Very High Very High Very High
Sprains And Strains 2 98.84 Very High Very High Very High
Lung Cancer 4 90.00 High High
Suicidal Behaviour 81 86.80 High High
Adhesions 12 81.12 Quite High
Neurodegenerative Disease 24 65.24 Quite High
Death 51 40.52 Quite Low
Breast Cancer 1 25.20 Quite Low
Convulsion 3 14.08 Low Low
Cancer 13 12.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Much more intense were the smoke-induced alterations of a variety of intermediate biomarkers, such as cytogenetic end points in pulmonary alveolar macrophages, bone marrow and peripheral blood erythrocytes; apoptosis, p53 oncoprotein, and proliferating cell nuclear antigen in the bronchial epithelium; bulky DNA adducts, 8-hydroxy-2-deoxyguanosine; multigene expression, and thiobarbituric acid-reactive aldehydes in whole lung and several other organs.
Positive_regulation (smoke-induced) of Gene_expression (expression) of proliferating cell nuclear antigen in epithelium associated with apoptosis
1) Confidence 0.49 Published 2005 Journal Exp. Lung Res. Section Abstract Doc Link 15765917 Disease Relevance 0.61 Pain Relevance 0.08
The induction of proliferation in a subset of bronchiolar cells and alveolar type II cells by Sox17 was associated with increased expression of several cyclin genes known to stimulate cell cycle progression.
Positive_regulation (increased) of Gene_expression (expression) of cyclin
2) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
In contrast, estrogen and sFasL, individually and together, induced cyclin-A expression, suggesting activation of compensatory survival mechanisms.


Positive_regulation (induced) of Gene_expression (expression) of cyclin
3) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Abstract Doc Link PMC395829 Disease Relevance 0.53 Pain Relevance 0
Estrogen and sFasL separately and together induce expression of cyclin A.


Positive_regulation (induce) of Gene_expression (expression) of cyclin
4) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.27 Pain Relevance 0.03
Both estrogen and sFasL alone led to a statistically significant increase in the expression of cyclin-A compared with controls at 12 hours post-treatment.
Positive_regulation (increase) of Gene_expression (expression) of cyclin
5) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.16 Pain Relevance 0

General Comments

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