INT125592

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.07
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1A) nucleoplasm (CDKN1A) nucleus (CDKN1A)
cell cycle (CDKN1A) kinase activity (CDKN1A) cytoplasm (CDKN1A)
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 6 81.92 Quite High
cytokine 1 25.00 Low Low
positron emission tomography 4 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 1 98.86 Very High Very High Very High
Congenital Anomalies 6 98.42 Very High Very High Very High
Testicular Cancer 147 96.86 Very High Very High Very High
Carcinoma In Situ 8 89.76 High High
Seminoma 32 88.80 High High
Ovarian Cancer 6 84.80 Quite High
Disease 28 76.28 Quite High
INFLAMMATION 2 75.00 Quite High
Cancer 60 73.16 Quite High
Colon Cancer 1 61.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we observed down-regulation of p21 WAF1/CIP1 by introduction of NAG-1 small interfering RNA into sulindac sulfide-treated cells.
Negative_regulation (down) of Negative_regulation (regulation) of CIP1
1) Confidence 0.42 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15767558 Disease Relevance 0.57 Pain Relevance 0.41
In particular, TGCT has been shown to be associated with a characteristic series of abnormalities in the retinoblastoma pathway including upregulation of cyclin D2 and p27 and downregulation of RB1 and the cyclin-dependent kinase inhibitors of p16, p18, p19 and p21 [13].
Negative_regulation (downregulation) of Negative_regulation (inhibitors) of p21 associated with congenital anomalies, testicular cancer and retinoblastoma
2) Confidence 0.08 Published 2008 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2735737 Disease Relevance 1.50 Pain Relevance 0

General Comments

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