INT125622

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 1.84
Pain Relevance 3.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NLRP1) nucleus (NLRP1) intracellular (NLRP1)
enzyme binding (NLRP1) cytoplasm (NLRP1)
Anatomy Link Frequency
nucleus accumbens 1
body 1
NLRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nucleus accumbens 74 100.00 Very High Very High Very High
Ventral tegmentum 54 100.00 Very High Very High Very High
cocaine 16 100.00 Very High Very High Very High
Dopamine 152 99.96 Very High Very High Very High
Paracetamol 13 99.90 Very High Very High Very High
gABA 8 99.54 Very High Very High Very High
Gabapentin 10 97.88 Very High Very High Very High
insula 2 97.08 Very High Very High Very High
addiction 20 91.04 High High
vincristine 1 89.60 High High
Disease Link Frequency Relevance Heat
Congenital Anomalies 1 99.16 Very High Very High Very High
Liver Cancer 3 98.56 Very High Very High Very High
Toxicity 10 93.12 High High
Skin Cancer 8 83.76 Quite High
Cancer 47 78.72 Quite High
Syndrome 28 75.00 Quite High
Unconsciousness 56 72.64 Quite High
Ovarian Cancer 2 70.60 Quite High
Cocaine Dependence 1 69.32 Quite High
Aging 2 68.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HDAC and NAC are effective and well tolerated for progressive hepatoblastoma.
Regulation (effective) of NAC associated with liver cancer and paracetamol
1) Confidence 0.44 Published 2005 Journal Pediatr Blood Cancer Section Abstract Doc Link 15770640 Disease Relevance 0.42 Pain Relevance 0.64
Because fetuses are exposed to MeHg via maternal blood and hence are prone to the danger of developmental abnormalities (Ornaghi et al. 1993), we determined the effectiveness of NAC in reducing the body burden of MeHg in pregnant dams.
Spec (determined) Regulation (effectiveness) of NAC in body associated with congenital anomalies
2) Confidence 0.28 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199271 Disease Relevance 0.10 Pain Relevance 0
Using fMRI, Menon and Levitin [9] clearly found for the first time that listening to music strongly modulates activity in a network of mesolimbic structures involved in reward processing including the nucleus accumbens (NAc) and the ventral tegmental area (VTA), as well as the hypothalamus, and insula, which are thought to be involved in regulating autonomic and physiological responses to rewarding and emotional stimuli.
Regulation (modulates) of NAc in nucleus accumbens associated with ventral tegmentum, nucleus accumbens and insula
3) Confidence 0.26 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 19914781 Disease Relevance 0.15 Pain Relevance 0.52
We detect the induction of both fibronectin and PAI1 in NHEK cells at both 12 and 24 hrs, suggesting a role of EGR1 pathways in the NAC mediated mechanism at least in this cell type.
Regulation (role) of NAC
4) Confidence 0.11 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.54 Pain Relevance 0
The NAc and VTA are especially sensitive to rewarding stimuli [63].
Regulation (sensitive) of NAc associated with ventral tegmentum and nucleus accumbens
5) Confidence 0.09 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.30 Pain Relevance 0.38
In order to identify genes with significant NAC treatment response at each time point for each cell line we applied a two-step filtering based on the t-test p-value of less than 0.1 (indicating statistically significant changes from the control value), and a biological fold cut-off of 1.5 fold (up or down).
Regulation (response) of NAC
6) Confidence 0.07 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0 Pain Relevance 0
In vivo microdialysis showed that the same doses of Gabapentin produced a modest increase (approximately 50%, p < 0.05) in extracellular NAc GABA levels, but failed to alter either basal or cocaine-enhanced NAc DA.
Neg (failed) Regulation (alter) of NAc associated with nucleus accumbens, dopamine, gaba, gabapentin and cocaine
7) Confidence 0.05 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0.32 Pain Relevance 1.70
Figure 3 summarizes the percent decrease in amplitude of the sensory (acoustic) evoked responses for P3 component as compared to control recording in the VTA, NAc, and PFC.
Regulation (control) of NAc associated with nucleus accumbens and ventral tegmentum
8) Confidence 0.00 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1360669 Disease Relevance 0 Pain Relevance 0.38

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