INT125624

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Context Info
Confidence 0.15
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 3.91
Pain Relevance 4.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
IB4 4
neurons 2
brain 2
hippocampus 2
nociceptors 1
Atp8a2 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 88 100.00 Very High Very High Very High
Calcitonin gene-related peptide 17 100.00 Very High Very High Very High
substance P 13 100.00 Very High Very High Very High
dorsal root ganglion 11 99.82 Very High Very High Very High
Hippocampus 55 99.68 Very High Very High Very High
Nav1.9 4 99.62 Very High Very High Very High
allodynia 47 96.72 Very High Very High Very High
superficial lamina 4 96.24 Very High Very High Very High
Spinal cord 30 95.20 Very High Very High Very High
Nerve growth factor 46 94.08 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 11 99.82 Very High Very High Very High
Stress 260 98.16 Very High Very High Very High
Neuropathic Pain 101 96.72 Very High Very High Very High
Nociception 35 95.92 Very High Very High Very High
Pain 66 89.60 High High
Repression 5 76.40 Quite High
Diabetes Mellitus 44 73.36 Quite High
Diabetic Neuropathy 36 72.60 Quite High
Cold Sores 10 68.64 Quite High
Targeted Disruption 21 67.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies in our laboratories found that isolectin B(4)(IB(4))-positive polymodal nociceptors in the mouse do not express transient receptor potential vanilloid 1 (TRPV1), nor does deletion of TRPV1 compromise the ability of these afferents to detect thermal stimuli.
Neg (not) Gene_expression (express) of IB in nociceptors associated with nociceptor
1) Confidence 0.15 Published 2006 Journal Neuroscience Section Abstract Doc Link 16564640 Disease Relevance 0 Pain Relevance 0.18
Enhanced M6a-Ib expression in the medial prefrontal cortex (in areas prelimbic and infralimbic cortex) might be interpreted as a compensatory mechanism in response to changes in axonal projections from the hippocampus.
Gene_expression (expression) of Ib in hippocampus associated with hippocampus
2) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2629568 Disease Relevance 0.50 Pain Relevance 0.14
As determined by quantitative real-time RT-PCR chronic restraint selectively downregulates neuronally expressed M6a isoform Ib in the hippocampus, but not isoform Ia.
Gene_expression (expressed) of Ib in hippocampus associated with hippocampus
3) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629568 Disease Relevance 0.26 Pain Relevance 0.27
In mammals, the TRPV subfamily is exclusively expressed in small- to medium-sized primary sensory neurons that also co-express some chemical markers (i.e. isolectin B4 (IB4), fluoride-resistant acid phosphatase (FRAP), the P2X3 purinoceptor (a receptor provoked by ATP-induced nociception) and Ret, a glial cell line-derived neurotrophic factor receptor).
Gene_expression (co-express) of IB4 in IB4 associated with nociception
4) Confidence 0.02 Published 2006 Journal Anat Sci Int Section Abstract Doc Link 16955665 Disease Relevance 0.16 Pain Relevance 0.47
The present quantitative RT-PCR analysis reveals that N-terminus variants of M6a are constitutively expressed at different levels within central and peripheral tissue: M6a isoform Ia is expressed at low levels in brain and kidney epithelia, whereas isoform Ib is highly expressed in the brain, but at very low levels in the kidneys.
Gene_expression (expressed) of Ib in kidney
5) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629568 Disease Relevance 0.32 Pain Relevance 0.07
The present data reveal that it is the splice variant M6a-Ib, not M6a-Ia, which is strongly expressed in the brain.
Gene_expression (expressed) of Ib in brain
6) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2629568 Disease Relevance 0.49 Pain Relevance 0.07
Nav1.9 is preferentially expressed in isolectin B4 (IB4)-positive neurons and thus we used this marker to subdivide small-diameter DRG neurons.
Gene_expression (expressed) of IB4 in neurons associated with dorsal root ganglion and nav1.9
7) Confidence 0.01 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16029194 Disease Relevance 0.43 Pain Relevance 1.16
This sequential photographing avoids the masking of low-level fluorescent signals by non-fluorescent in situ signals, leading to a more sensitive detection of the coexpression of Runx1, CGRP, or IB4 with genes of interest.
Gene_expression (coexpression) of IB4 in IB4
8) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0 Pain Relevance 0
These results are consistent with our previous findings that GDNF expression and the percentages of IB4-labelled neurons do not change in db/db mice [15].
Gene_expression (expression) of IB4-labelled in neurons
9) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.77 Pain Relevance 1.19
The present quantitative RT-PCR analysis reveals that N-terminus variants of M6a are constitutively expressed at different levels within central and peripheral tissue: M6a isoform Ia is expressed at low levels in brain and kidney epithelia, whereas isoform Ib is highly expressed in the brain, but at very low levels in the kidneys.
Gene_expression (expressed) of Ib in brain
10) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629568 Disease Relevance 0.32 Pain Relevance 0.07
Previous studies indicate that some DRG neurons express both CGRP and IB4 binding.
Gene_expression (express) of IB4 in IB4 associated with dorsal root ganglion and calcitonin gene-related peptide
11) Confidence 0.00 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 15770655 Disease Relevance 0.40 Pain Relevance 0.77
Indeed, more frequent colocalization of eGFP was observed with markers of small DRG neurons (TRPV1, Substance P, CGRP, TrkA and IB4) than with large neurons (NF200) in the DRG. eGFP-positive fibers were present mainly in the superficial lamina of the spinal cord and colocalized extensively with CGRP1 (lamina I and II outer) and less with IB4 (lamina II inner) suggesting an enriched transduction of peptidergic neurons following this route of administration.
Gene_expression (neurons) of IB4 in IB4 associated with superficial lamina, spinal cord, calcitonin gene-related peptide and substance p
12) Confidence 0.00 Published 2009 Journal Mol Pain Section Body Doc Link PMC2747840 Disease Relevance 0.25 Pain Relevance 0.47

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