INT125627

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2009
Negated 8
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 12.68
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TTF1) nucleolus (TTF1) nucleus (TTF1)
DNA binding (TTF1)
Anatomy Link Frequency
lung 4
thyroid 3
smooth muscle 1
jejunum 1
skeletal muscle 1
TTF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
iatrogenic 2 95.92 Very High Very High Very High
abdominal pain 2 92.92 High High
anesthesia 3 91.72 High High
Pain 9 85.24 High High
Angina 3 70.16 Quite High
dexamethasone 1 49.96 Quite Low
corticosteroid 3 38.44 Quite Low
fibrosis 1 34.84 Quite Low
imagery 6 29.84 Quite Low
cva 15 27.44 Quite Low
Disease Link Frequency Relevance Heat
Lung Cancer 95 100.00 Very High Very High Very High
Thyroid Neoplasm 9 99.90 Very High Very High Very High
Cancer 148 99.32 Very High Very High Very High
Adenocarcinoma 19 98.88 Very High Very High Very High
Malignant Neoplastic Disease 65 98.62 Very High Very High Very High
Carcinoma 48 97.24 Very High Very High Very High
Bone Cancer 21 97.20 Very High Very High Very High
Thyroid Nodule 1 94.48 High High
Abdominal Pain 2 92.92 High High
Hepatocellular Cancer 22 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Case with double primary cancers occurring synchronously in both the lung and jejunum diagnosed according to TTF-1 expression].
Gene_expression (expression) of TTF-1 in jejunum associated with cancer
1) Confidence 0.78 Published 2005 Journal Nihon Kokyuki Gakkai Zasshi Section Title Doc Link 15770938 Disease Relevance 0.81 Pain Relevance 0.18
Later, the immunohistochemical examination revealed that cytokeratin 7 (CK7) and thyroid transcription factor 1 (TTF-1) were distinctly detected but cytokeratin 20 (CK20) never expressed.
Gene_expression (detected) of TTF-1 in thyroid
2) Confidence 0.58 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1821329 Disease Relevance 1.19 Pain Relevance 0.09
Immunohistochemical staining showed that the thyroid carcinoma was negative for thyroid transcription factor-1 (TTF-1), CK 7, CK 20, and thyroglobulin.
Neg (negative) Gene_expression (negative) of TTF-1 in thyroid associated with thyroid neoplasm
3) Confidence 0.53 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2246133 Disease Relevance 1.42 Pain Relevance 0
Recently, Chhieng et al. described that an adenocarcinoma was likely a primary lung tumor when it was of the CK7 positive/CK20 negative and TTF-1 positive phenotype [1].
Neg (negative) Gene_expression (negative) of TTF-1 in lung associated with adenocarcinoma and lung cancer
4) Confidence 0.50 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1821329 Disease Relevance 1.30 Pain Relevance 0.08
Recently, Chhieng et al. described that an adenocarcinoma was likely a primary lung tumor when it was of the CK7 positive/CK20 negative and TTF-1 positive phenotype [1].
Neg (negative) Gene_expression (positive) of TTF-1 in lung associated with adenocarcinoma and lung cancer
5) Confidence 0.50 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1821329 Disease Relevance 1.30 Pain Relevance 0.08
Furthermore, immunoperoxidase stains for thyroglobulin and TTF-1 were negative, excluding the possibility of a thyroid neoplasm.
Neg (negative) Gene_expression (negative) of TTF-1 in thyroid associated with thyroid neoplasm
6) Confidence 0.50 Published 2005 Journal Cytojournal Section Body Doc Link PMC1184093 Disease Relevance 0.63 Pain Relevance 0.09
CK7 (OV-TL 12/30, 1:60, DAKO), CK20 (KS 20.8, 1:20, DAKO), EMA (E29, 1:50, DAKO), CEAm (12-140-10, 1:50, NOVOCASTRA), CEAp (Rabbit anti-human polyclonal antibody, 1:4000, DAKO), TTF-1 (8G7G3/1 1:40, ZYMED), Chromogranin (DAK-A3, 1:20, DAKO) and S-100 (Rabbit anti-human polyclonal antibody, 1:1000, DAKO) were negative.
Neg (negative) Gene_expression (negative) of TTF-1
7) Confidence 0.29 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2630932 Disease Relevance 0.45 Pain Relevance 0
The biopsy contains some skeletal muscle and some pleura with a thick layer of malignant epithelioid cells which are positive for mesothelial markers CK5/6 and Calretinin and negative for lung cancer markers TTF-1 and CEA.
Neg (negative) Gene_expression (negative) of TTF-1 in skeletal muscle associated with malignant neoplastic disease and lung cancer
8) Confidence 0.29 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2777157 Disease Relevance 1.55 Pain Relevance 0.07
A panel of immunohistochemical markers were performed and these malignant cells are positive for mesothelial markers CK5/6 and Calretinin and negative for lung cancer markers TTF-1 and CEA.
Neg (negative) Gene_expression (negative) of TTF-1 in lung associated with malignant neoplastic disease and lung cancer
9) Confidence 0.29 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2777157 Disease Relevance 1.24 Pain Relevance 0
[Case with double primary cancers occurring synchronously in both the lung and jejunum diagnosed according to TTF-1 expression].
Gene_expression (expression) of TTF-1 in lung associated with cancer
10) Confidence 0.26 Published 2005 Journal Nihon Kokyuki Gakkai Zasshi Section Title Doc Link 15770938 Disease Relevance 0.81 Pain Relevance 0.18
All of the neoplastic cells were negative for EMA, CDX2 and TTF-1, and no evident tumor cell mucin production was seen on mucicarmine and DPAS staining.
Neg (negative) Gene_expression (negative) of TTF-1 associated with cancer
11) Confidence 0.14 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2034570 Disease Relevance 1.45 Pain Relevance 0
The neoplastic cells were negative for CD43, ALK, CD30, EMA, smooth muscle actin, cytokeratin, desmin, myogenin, TTF1, CD99, CD1a, LMP-1, CD117, HMB45, and Mart-1/Melan A.
Gene_expression (negative) of TTF1 in smooth muscle
12) Confidence 0.12 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 0.54 Pain Relevance 0

General Comments

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