INT12563

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Context Info
Confidence 0.81
First Reported 1991
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 33
Total Number 34
Disease Relevance 20.99
Pain Relevance 9.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mpo) extracellular space (Mpo) aging (Mpo)
Anatomy Link Frequency
PMN 9
leukocyte 3
plasma 2
spinal 2
neurons 2
Mpo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 12 99.86 Very High Very High Very High
bradykinin 8 99.84 Very High Very High Very High
Inflammatory mediators 4 99.84 Very High Very High Very High
Inflammation 123 99.72 Very High Very High Very High
qutenza 12 99.72 Very High Very High Very High
Angina 13 99.62 Very High Very High Very High
Versed 14 99.44 Very High Very High Very High
vincristine 9 99.44 Very High Very High Very High
narcan 8 97.22 Very High Very High Very High
cva 9 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 189 100.00 Very High Very High Very High
Myocardial Infarction 44 100.00 Very High Very High Very High
Hypoxia 2 99.96 Very High Very High Very High
INFLAMMATION 129 99.84 Very High Very High Very High
Angina 9 99.62 Very High Very High Very High
Coronary Artery Disease 17 96.84 Very High Very High Very High
Cv General 3 Under Development 13 96.84 Very High Very High Very High
Pleurisy 1 96.16 Very High Very High Very High
Stress 24 96.00 Very High Very High Very High
Pressure And Volume Under Development 1 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MPO secretion by stimulated neutrophils acts, thus, as a host defense mechanism by efficiently mediating microbial killing.
Localization (secretion) of MPO in neutrophils associated with urological neuroanatomy
1) Confidence 0.81 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2804053 Disease Relevance 1.10 Pain Relevance 0.23
Given that MPO is a lysosomal enzyme that can be released into the circulation by both normal activated and leukemic myeloid cells, we investigated the possibility that sera from patients with acute myeloblastic leukemia (AML) might exhibit an increased capacity to degrade VCR. 31 serum samples (23 from patients with acute myeloblastic leukemia and 8 from patients with other conditions) were analyzed after incubation with ((3)H)VCR by using HPLC.
Localization (released) of MPO in myeloid cells associated with vincristine, acute myeloid leukemia and urological neuroanatomy
2) Confidence 0.80 Published 1996 Journal Leuk. Lymphoma Section Abstract Doc Link 8833400 Disease Relevance 0.60 Pain Relevance 0.28
In vitro tests include some studies of leukocyte functions, such as superoxide production and myeloperoxidase release.
Localization (release) of myeloperoxidase in leukocyte
3) Confidence 0.78 Published 1993 Journal J Pharm Sci Section Abstract Doc Link 8395598 Disease Relevance 0.44 Pain Relevance 0.26
In this study we tested the hypothesis that levels of MPO in plasma after a myocardial infarction are affected by its ability to bind to the endothelium and there is local release of the enzyme at the culprit lesion.
Localization (release) of MPO in plasma associated with urological neuroanatomy and myocardial infarction
4) Confidence 0.75 Published 2010 Journal Am. J. Cardiol. Section Abstract Doc Link 20643239 Disease Relevance 0.86 Pain Relevance 0.07
Myeloperoxidase (MPO), a heme protein abundantly expressed and secreted by polymorphonuclear neutrophils (PMN), has emerged as a critical mediator in coronary atherosclerosis.
Localization (secreted) of Myeloperoxidase in PMN associated with coronary artery disease and urological neuroanatomy
5) Confidence 0.74 Published 2009 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19362143 Disease Relevance 0.84 Pain Relevance 0
Myeloperoxidase (MPO), a heme protein abundantly expressed and secreted by polymorphonuclear neutrophils (PMN), has emerged as a critical mediator in coronary atherosclerosis.
Localization (secreted) of MPO in PMN associated with coronary artery disease and urological neuroanatomy
6) Confidence 0.74 Published 2009 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19362143 Disease Relevance 0.84 Pain Relevance 0
E to TL ratio and myeloperoxidase (MPO) were studied in 20 patients undergoing lumbar spinal surgery and randomly allocated to two anesthetic groups: propofol (bolus dose + continuous infusion and thiopental/isoflurane.
Localization (allocated) of myeloperoxidase in spinal associated with urological neuroanatomy and isoflurane
7) Confidence 0.71 Published 1991 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 1649539 Disease Relevance 0.17 Pain Relevance 0.26
E to TL ratio and myeloperoxidase (MPO) were studied in 20 patients undergoing lumbar spinal surgery and randomly allocated to two anesthetic groups: propofol (bolus dose + continuous infusion and thiopental/isoflurane.
Localization (allocated) of MPO in spinal associated with urological neuroanatomy and isoflurane
8) Confidence 0.71 Published 1991 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 1649539 Disease Relevance 0.17 Pain Relevance 0.26
OBJECTIVES: Inflammation, a major risk factor for acute myocardial infarction (AMI), is associated with leukocytic activation, secretion of myeloperoxidase (MPO) and generation of the oxidative damage marker, 3-chlorotyrosine (3-Cl-Tyr).
Localization (secretion) of MPO associated with inflammation, urological neuroanatomy and myocardial infarction
9) Confidence 0.71 Published 2008 Journal Clin. Biochem. Section Abstract Doc Link 18314009 Disease Relevance 0.74 Pain Relevance 0.12
OBJECTIVES: Inflammation, a major risk factor for acute myocardial infarction (AMI), is associated with leukocytic activation, secretion of myeloperoxidase (MPO) and generation of the oxidative damage marker, 3-chlorotyrosine (3-Cl-Tyr).
Localization (secretion) of myeloperoxidase associated with inflammation, urological neuroanatomy and myocardial infarction
10) Confidence 0.71 Published 2008 Journal Clin. Biochem. Section Abstract Doc Link 18314009 Disease Relevance 0.74 Pain Relevance 0.12
Serial blood samples taken between 1 and 24 h after the onset of chest pain were analyzed for MPO, TnT, creatine kinase MB, myoglobin, and high sensitive C-reactive protein.
Spec (analyzed) Localization (creatine kinase MB) of MPO in chest associated with angina and urological neuroanatomy
11) Confidence 0.69 Published 2009 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19362143 Disease Relevance 1.86 Pain Relevance 0.10
Using double immunofluorescence confocal microscopy, we showed that beta-endorphin (END) and Met-enkephalin (ENK) were colocalized with the primary (azurophil) granule markers CD63 and myeloperoxidase (MPO) within PMN.
Localization (colocalized) of MPO in PMN associated with urological neuroanatomy and enkephalin
12) Confidence 0.69 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17604950 Disease Relevance 0.32 Pain Relevance 1.02
Using double immunofluorescence confocal microscopy, we showed that beta-endorphin (END) and Met-enkephalin (ENK) were colocalized with the primary (azurophil) granule markers CD63 and myeloperoxidase (MPO) within PMN.
Localization (colocalized) of myeloperoxidase in PMN associated with urological neuroanatomy and enkephalin
13) Confidence 0.69 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17604950 Disease Relevance 0.32 Pain Relevance 1.01
In vitro measurements included myeloperoxidase activity, plasma corticosterone levels, interleukin 1 beta messenger RNA expression, and [3H]noradrenaline release from the myenteric plexus.
Localization (release) of myeloperoxidase in plasma
14) Confidence 0.69 Published 1996 Journal Gastroenterology Section Body Doc Link 8942729 Disease Relevance 0.17 Pain Relevance 0
Myocardial I/R injury initiates an acute inflammatory response.23 Accumulation of polymorphonuclear leukocytes (PMNs) is major evidence of acute inflammation, and the infiltration of PMNs initiates myocardial damage by releasing oxygen free radicals, proteases, and leukotrienes.23,24 The MPO activity assay for PMN activation should be checked because MPO is mainly released from PMNs.24,25 In the present study, MPO activity was inhibited by EP treatment; thus, EP may exert a protective effect by inhibiting PMN activity.
Localization (released) of MPO in polymorphonuclear leukocytes associated with inflammatory response, inflammation, injury and urological neuroanatomy
15) Confidence 0.68 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2995973 Disease Relevance 1.43 Pain Relevance 0.23
Given its pro-inflammatory properties, the potential implication of MPO release on clinical outcome in stable patients undergoing stenting needs further investigation.


Localization (release) of MPO
16) Confidence 0.67 Published 2009 Journal Eur. J. Intern. Med. Section Body Doc Link 19712859 Disease Relevance 0 Pain Relevance 0
BACKGROUND: During inflammation, myeloperoxidase (MPO) is released, for which its measurement in systemic circulation may be used as an index of leukocyte activation and oxidant stress.
Localization (released) of myeloperoxidase in leukocyte associated with stress, inflammation and urological neuroanatomy
17) Confidence 0.64 Published 2006 Journal Am. J. Kidney Dis. Section Abstract Doc Link 16797387 Disease Relevance 0.64 Pain Relevance 0.13
BACKGROUND: During inflammation, myeloperoxidase (MPO) is released, for which its measurement in systemic circulation may be used as an index of leukocyte activation and oxidant stress.
Localization (released) of MPO in leukocyte associated with stress, inflammation and urological neuroanatomy
18) Confidence 0.64 Published 2006 Journal Am. J. Kidney Dis. Section Abstract Doc Link 16797387 Disease Relevance 0.64 Pain Relevance 0.13
The second is that ANCA antigens such as MPO undergo translocation to the surface of neutrophils (possibly in response to proinflammatory cytokines), and subsequent binding of circulating ANCA results in neutrophil degranulation and the release of reactive oxygen species, causing injury and consequent fibrosis [5,6].
Localization (undergo) of MPO in neutrophil associated with fibrosis, injury, urological neuroanatomy and cytokine
19) Confidence 0.62 Published 2010 Journal NDT Plus Section Body Doc Link PMC2904803 Disease Relevance 1.88 Pain Relevance 0.52
Myeloperoxidase measurements
Localization (measurements) of Myeloperoxidase
20) Confidence 0.58 Published 2002 Journal BMC Physiol Section Body Doc Link PMC126222 Disease Relevance 0.14 Pain Relevance 0.24

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