INT12564

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Context Info
Confidence 0.81
First Reported 1980
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 23
Total Number 23
Disease Relevance 4.37
Pain Relevance 5.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pthlh) Golgi apparatus (Pthlh) nucleolus (Pthlh)
nucleus (Pthlh) intracellular (Pthlh) cellular_component (Pthlh)
Anatomy Link Frequency
parathyroid 3
hypothalamus 2
spinal cord 1
brain 1
nucleus 1
Pthlh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
c fibre 2 99.30 Very High Very High Very High
narcan 23 99.24 Very High Very High Very High
antagonist 36 99.16 Very High Very High Very High
bradykinin 5 99.12 Very High Very High Very High
substance P 9 99.08 Very High Very High Very High
agonist 5 98.92 Very High Very High Very High
Kinase C 5 98.76 Very High Very High Very High
Neurotransmitter 6 98.74 Very High Very High Very High
opiate 1 98.56 Very High Very High Very High
qutenza 9 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Thymoma 24 99.08 Very High Very High Very High
Hypercalcemia 10 98.48 Very High Very High Very High
Parathyroid Cancer 1 97.84 Very High Very High Very High
Hyperplasia 1 96.92 Very High Very High Very High
Malignant Neoplastic Disease 5 96.00 Very High Very High Very High
Increased Venous Pressure Under Development 5 95.76 Very High Very High Very High
Hyponatremia 3 94.60 High High
Sarcoidosis 26 93.56 High High
Dysmenorrhea 2 91.52 High High
Uveitis 2 89.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with phorbol myristate acetate or 1-oleoyl-2-acetyl-sn-glycerol produced a dose-related, 2- to 4-fold increase in PTHrP secretion.
Localization (secretion) of PTHrP
1) Confidence 0.81 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 7946399 Disease Relevance 0.13 Pain Relevance 0.19
Cultured type II cells secreted PTHrP into medium, 202 +/- 11 fg PTHrP/micrograms cell protein in 24 h.
Localization (secreted) of PTHrP
2) Confidence 0.81 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 7946399 Disease Relevance 0.15 Pain Relevance 0.15
Cultured type II cells secreted PTHrP into medium, 202 +/- 11 fg PTHrP/micrograms cell protein in 24 h.
Localization (secreted) of PTHrP
3) Confidence 0.81 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 7946399 Disease Relevance 0.15 Pain Relevance 0.15
Thus, PTHrP secretion appeared to be regulated by a protein kinase C-dependent pathway.
Localization (secretion) of PTHrP associated with kinase c
4) Confidence 0.81 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 7946399 Disease Relevance 0.12 Pain Relevance 0.20
Effect of low-frequency stimulation of the pituitary stalk on neurohypophysial hormone release in vivo.
Localization (release) of neurohypophysial hormone in pituitary stalk
5) Confidence 0.77 Published 1980 Journal Neuroendocrinology Section Title Doc Link 7189831 Disease Relevance 0.18 Pain Relevance 0.18
Alveolar epithelial cells express and secrete parathyroid hormone-related protein.
Localization (secrete) of hormone-related protein in parathyroid
6) Confidence 0.70 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Title Doc Link 7946399 Disease Relevance 0.19 Pain Relevance 0.11
Evidence for an excitatory action of the benzodiazepine receptor inverse agonist FG 7142 on C-fibre afferents.

(1) The stimulation of adrenocorticotrophic hormone (ACTH) release by FG 7142 was found to be 50% inhibited in capsaicin-desensitized rats indicating that the excitatory effect of this inverse benzodiazepine agonist is partly mediated through capsaicin-sensitive afferents. (2) The in vitro release of substance P from spinal cord slices was stimulated in a tetrodotoxin-resistant manner by FG 7142.

Localization (release) of adrenocorticotrophic hormone in spinal cord associated with tetrodotoxin, c fibre, qutenza, agonist, spinal cord and substance p
7) Confidence 0.15 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 2478895 Disease Relevance 0 Pain Relevance 0.87
The effect of neurotransmitter receptor antagonists on the inhibitory effect of melatonin on neurohypophysial hormone release from the rat hypothalamus in vitro was therefore determined.
Localization (release) of neurohypophysial hormone in hypothalamus associated with neurotransmitter and antagonist
8) Confidence 0.14 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9434202 Disease Relevance 0 Pain Relevance 0.51
Mechanisms of melatonin inhibition of neurohypophysial hormone release from the rat hypothalamus in vitro.
Localization (release) of neurohypophysial hormone in hypothalamus associated with narcan
9) Confidence 0.14 Published 1998 Journal Brain Res. Bull. Section Title Doc Link 9434202 Disease Relevance 0 Pain Relevance 0.62
Although melatonin has been reported to influence neurohypophysial hormone release, no binding has been demonstrated in the neurohypophysial system, suggesting melatonin could affect afferent inputs.
Localization (release) of neurohypophysial hormone
10) Confidence 0.14 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9434202 Disease Relevance 0 Pain Relevance 0.30
This study suggests that melatonin may influence neurohypophysial hormone release through modulation of afferent pathways mediated by acetylcholine, dopamine, and/or prostaglandin.
Localization (release) of neurohypophysial hormone associated with dopamine
11) Confidence 0.14 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9434202 Disease Relevance 0 Pain Relevance 0.52
Substance P dose-dependently (0.01-10 micrograms i.c.v.) released oxytocin but not vasopressin or adrenocorticotropic hormone (ACTH) from the pituitary gland.
Neg (not) Localization (released) of hormone in pituitary gland associated with substance p
12) Confidence 0.09 Published 1988 Journal Circ. Res. Section Abstract Doc Link 2458861 Disease Relevance 0.46 Pain Relevance 0.30
To explore mechanisms of osmotic control of neurohypophysial hormone release, electrical activity of magnocellular neurons (MCNs) in the hypothalamus, related neurons and efferent renal sympathetic nerve activity (RSNA) were recorded from urethane-anesthetized rats.
Localization (release) of neurohypophysial hormone in neurons
13) Confidence 0.09 Published 2003 Journal J. Reprod. Dev. Section Abstract Doc Link 14967944 Disease Relevance 0 Pain Relevance 0
Mechanisms controlling neurohypophysial hormone release in the rat.
Localization (release) of neurohypophysial hormone
14) Confidence 0.08 Published 2003 Journal J. Reprod. Dev. Section Title Doc Link 14967944 Disease Relevance 0 Pain Relevance 0.05
In gilthead sea bream (Sparus auratus), these somatolactotrophs have been found to co-localize with parathyroid hormone related protein (PTHrP) cells and in some instances, both hormones are found in the same cell [30,31].
Localization (localize) of parathyroid hormone related protein in parathyroid
15) Confidence 0.05 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553077 Disease Relevance 0 Pain Relevance 0
The median preoptic nucleus (MnPO) of the hypothalamus is involved in the osmotic control of neurohypophysial hormone release and drinking behavior.
Localization (release) of neurohypophysial hormone in nucleus
16) Confidence 0.05 Published 2000 Journal Brain Res. Section Abstract Doc Link 10837803 Disease Relevance 0 Pain Relevance 0.07
The data indicate that the sites of inhibition of neurohypophysial hormone release due to beta-endorphin-(1-31) are more likely to be located mostly within the blood-brain barrier, to which methyl naloxone has less ready access, than are the sites of inhibition due to dynorphin A-(1-13).
Localization (release) of neurohypophysial hormone in brain associated with dynorphin and narcan
17) Confidence 0.04 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1680708 Disease Relevance 0.08 Pain Relevance 0.68
Considering the mechanism of the observed changes in tyrosine hydroxylase activity it is concluded that the changes are mediated by neural pathways and that variations in the secretion of adrenocorticotrophic hormone (ACTH) do not play a role.
Localization (secretion) of adrenocorticotrophic hormone in neural
18) Confidence 0.03 Published 1983 Journal Neuropharmacology Section Abstract Doc Link 6133231 Disease Relevance 0 Pain Relevance 0.36
Control of neurohypophysial hormone secretion, blood osmolality and volume in pregnancy.
Localization (secretion) of neurohypophysial hormone in blood
19) Confidence 0.02 Published 2008 Journal J. Physiol. Pharmacol. Section Title Doc Link 19258663 Disease Relevance 0.42 Pain Relevance 0.11
Hypercalcemia in patients with thymoma can be seen due to the following reasons, namely, secretion of parathyroid-related protein (PTHrP) or PTH by the thymoma itself, coexistence of parathyroid adenoma or hyperplasia of parathyroid gland [7].
Localization (secretion) of parathyroid-related protein in parathyroid associated with parathyroid cancer, thymoma, hypercalcemia and hyperplasia
20) Confidence 0.02 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2500026 Disease Relevance 2.21 Pain Relevance 0

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