INT125640

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.09
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp3a2) endoplasmic reticulum (Cyp3a2) enzyme binding (Cyp3a2)
cytoplasm (Cyp3a2)
Cyp3a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Oxycodone 4 50.00 Quite Low
IPN 1 50.00 Quite Low
Inflammation 6 10.00 Low Low
Pain 2 10.00 Low Low
Kinase C 2 6.00 Low Low
cytokine 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 20 91.44 High High
Inflammatory Pain 1 50.00 Quite Low
Adenovirus Infection 14 39.04 Quite Low
Targeted Disruption 2 20.44 Low Low
Toxicity 8 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Hepatotoxicity 6 5.00 Very Low Very Low Very Low
Heart Rate Under Development 4 5.00 Very Low Very Low Very Low
Viral Infection 4 5.00 Very Low Very Low Very Low
Pulmonary Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Repeated oxycodone administration is associated with a significant up-regulation of rGSTA5 and concomitant down-regulation of CYP3A2 mRNA, protein expression and functionality.
Regulation (regulation) of CYP3A2
1) Confidence 0.45 Published 2010 Journal J. Pharm. Pharmacol. Section Body Doc Link 20487198 Disease Relevance 0 Pain Relevance 0
CYP3A1 mRNA levels were severely decreased by FCA administration, whereas CYP3A2 mRNA and protein levels remained unchanged.
Neg (unchanged) Regulation (unchanged) of CYP3A2
2) Confidence 0.44 Published 2005 Journal Pharm. Res. Section Body Doc Link 15771231 Disease Relevance 0 Pain Relevance 0
Contrary to these findings, the UV inactivated virus did not alter CYP3A2 mRNA.
Neg (not) Regulation (alter) of CYP3A2 mRNA
3) Confidence 0.23 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0 Pain Relevance 0
Data from in vitro studies and microarray analysis of hepatic tissue provide further support that notion that engagement of integrin receptors, common points of entry for many pathogenic organisms [37], is sufficient to initiate changes in CYP3A2.
Regulation (changes) of CYP3A2
4) Confidence 0.23 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.09 Pain Relevance 0

General Comments

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