INT12565

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 0.71
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pthlh) Golgi apparatus (Pthlh) nucleolus (Pthlh)
nucleus (Pthlh) intracellular (Pthlh) cellular_component (Pthlh)
Anatomy Link Frequency
blood 2
hypothalamus 2
neurons 2
nucleus 2
pituitary stalk 2
Pthlh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 27 100.00 Very High Very High Very High
Neurotransmitter 3 100.00 Very High Very High Very High
Kinase C 1 99.76 Very High Very High Very High
bradykinin 1 99.12 Very High Very High Very High
opiate 1 98.56 Very High Very High Very High
qutenza 1 98.48 Very High Very High Very High
substance P 1 97.56 Very High Very High Very High
Dopamine 3 97.28 Very High Very High Very High
Dismenorea 2 91.52 High High
Opioid 7 82.76 Quite High
Disease Link Frequency Relevance Heat
Hyponatremia 3 94.60 High High
Dysmenorrhea 2 91.52 High High
Pressure And Volume Under Development 1 85.64 High High
Natriuresis 2 83.56 Quite High
Malignant Neoplastic Disease 1 59.80 Quite High
Hypercalcemia 1 58.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, PTHrP secretion appeared to be regulated by a protein kinase C-dependent pathway.
Regulation (regulated) of Localization (secretion) of PTHrP associated with kinase c
1) Confidence 0.62 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 7946399 Disease Relevance 0.12 Pain Relevance 0.20
Effect of low-frequency stimulation of the pituitary stalk on neurohypophysial hormone release in vivo.
Regulation (Effect) of Localization (release) of neurohypophysial hormone in pituitary stalk
2) Confidence 0.26 Published 1980 Journal Neuroendocrinology Section Title Doc Link 7189831 Disease Relevance 0.18 Pain Relevance 0.18
Although melatonin has been reported to influence neurohypophysial hormone release, no binding has been demonstrated in the neurohypophysial system, suggesting melatonin could affect afferent inputs.
Regulation (influence) of Localization (release) of neurohypophysial hormone
3) Confidence 0.10 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9434202 Disease Relevance 0 Pain Relevance 0.30
The effect of neurotransmitter receptor antagonists on the inhibitory effect of melatonin on neurohypophysial hormone release from the rat hypothalamus in vitro was therefore determined.
Regulation (effect) of Localization (release) of neurohypophysial hormone in hypothalamus associated with neurotransmitter and antagonist
4) Confidence 0.08 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9434202 Disease Relevance 0 Pain Relevance 0.51
To explore mechanisms of osmotic control of neurohypophysial hormone release, electrical activity of magnocellular neurons (MCNs) in the hypothalamus, related neurons and efferent renal sympathetic nerve activity (RSNA) were recorded from urethane-anesthetized rats.
Regulation (control) of Localization (release) of neurohypophysial hormone in neurons
5) Confidence 0.07 Published 2003 Journal J. Reprod. Dev. Section Abstract Doc Link 14967944 Disease Relevance 0 Pain Relevance 0
Mechanisms controlling neurohypophysial hormone release in the rat.
Regulation (controlling) of Localization (release) of neurohypophysial hormone
6) Confidence 0.06 Published 2003 Journal J. Reprod. Dev. Section Title Doc Link 14967944 Disease Relevance 0 Pain Relevance 0.05
This study suggests that melatonin may influence neurohypophysial hormone release through modulation of afferent pathways mediated by acetylcholine, dopamine, and/or prostaglandin.
Spec (may) Regulation (influence) of Localization (release) of neurohypophysial hormone associated with dopamine
7) Confidence 0.05 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9434202 Disease Relevance 0 Pain Relevance 0.52
The median preoptic nucleus (MnPO) of the hypothalamus is involved in the osmotic control of neurohypophysial hormone release and drinking behavior.
Regulation (control) of Localization (release) of neurohypophysial hormone in nucleus
8) Confidence 0.04 Published 2000 Journal Brain Res. Section Abstract Doc Link 10837803 Disease Relevance 0 Pain Relevance 0.07
Control of neurohypophysial hormone secretion, blood osmolality and volume in pregnancy.
Regulation (Control) of Localization (secretion) of neurohypophysial hormone in blood
9) Confidence 0.01 Published 2008 Journal J. Physiol. Pharmacol. Section Title Doc Link 19258663 Disease Relevance 0.42 Pain Relevance 0.11
The effect of dexmedetomidine, 10(-8)-10(-3) M, on adrenocorticotrophic hormone (ACTH) stimulated release of corticosterone was assessed in isolated rat adrenal cells.
Regulation (effect) of Localization (release) of adrenocorticotrophic hormone
10) Confidence 0.00 Published 1991 Journal Anesth. Analg. Section Abstract Doc Link 1649559 Disease Relevance 0 Pain Relevance 0.07
Although many peptides have been reported in the vicinity of hypothalamic magnocellular nuclei, their role in the control of neurohypophysial hormone release was only studied for few peptides: opiates, angiotensin II, substance P, CRF, oxytocin and vasopressin.
Regulation (role) of Localization (release) of neurohypophysial hormone associated with opiate and substance p
11) Confidence 0.00 Published 1985 Journal Ann. Endocrinol. (Paris) Section Abstract Doc Link 2417539 Disease Relevance 0 Pain Relevance 0.15

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