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Context Info
Confidence 0.70
First Reported 1989
Last Reported 1998
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.13
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pthlh) Golgi apparatus (Pthlh) nucleolus (Pthlh)
nucleus (Pthlh) intracellular (Pthlh) cellular_component (Pthlh)
Anatomy Link Frequency
spinal cord 2
Pthlh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
c fibre 2 99.60 Very High Very High Very High
agonist 2 99.22 Very High Very High Very High
qutenza 5 98.20 Very High Very High Very High
Dopamine 1 97.28 Very High Very High Very High
bradykinin 1 94.56 High High
substance P 1 90.56 High High
Spinal cord 2 89.88 High High
tetrodotoxin 1 88.32 High High
Kinase C 1 88.32 High High
Opioid 2 82.76 Quite High
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 1 64.88 Quite High
Hypercalcemia 1 63.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with phorbol myristate acetate or 1-oleoyl-2-acetyl-sn-glycerol produced a dose-related, 2- to 4-fold increase in PTHrP secretion.
Positive_regulation (increase) of Localization (secretion) of PTHrP
1) Confidence 0.70 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 7946399 Disease Relevance 0.13 Pain Relevance 0.19
This study suggests that melatonin may influence neurohypophysial hormone release through modulation of afferent pathways mediated by acetylcholine, dopamine, and/or prostaglandin.
Spec (may) Positive_regulation (influence) of Localization (release) of neurohypophysial hormone associated with dopamine
2) Confidence 0.09 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9434202 Disease Relevance 0 Pain Relevance 0.52
Evidence for an excitatory action of the benzodiazepine receptor inverse agonist FG 7142 on C-fibre afferents.

(1) The stimulation of adrenocorticotrophic hormone (ACTH) release by FG 7142 was found to be 50% inhibited in capsaicin-desensitized rats indicating that the excitatory effect of this inverse benzodiazepine agonist is partly mediated through capsaicin-sensitive afferents. (2) The in vitro release of substance P from spinal cord slices was stimulated in a tetrodotoxin-resistant manner by FG 7142.

Positive_regulation (stimulation) of Localization (release) of adrenocorticotrophic hormone in spinal cord associated with tetrodotoxin, c fibre, qutenza, agonist, spinal cord and substance p
3) Confidence 0.09 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 2478895 Disease Relevance 0 Pain Relevance 0.87
The effect of dexmedetomidine, 10(-8)-10(-3) M, on adrenocorticotrophic hormone (ACTH) stimulated release of corticosterone was assessed in isolated rat adrenal cells.
Positive_regulation (stimulated) of Localization (release) of adrenocorticotrophic hormone
4) Confidence 0.00 Published 1991 Journal Anesth. Analg. Section Abstract Doc Link 1649559 Disease Relevance 0 Pain Relevance 0.07

General Comments

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