INT12569

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.81
First Reported 1985
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 94
Total Number 127
Disease Relevance 23.81
Pain Relevance 104.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
neutrophils 11
brain 7
immune cells 3
neurons 3
dentate gyrus 2
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 2774 100.00 Very High Very High Very High
Enkephalin 1426 100.00 Very High Very High Very High
opioid receptor 1128 100.00 Very High Very High Very High
agonist 654 100.00 Very High Very High Very High
antagonist 587 100.00 Very High Very High Very High
narcan 335 100.00 Very High Very High Very High
Endogenous opioid 226 100.00 Very High Very High Very High
Morphine 195 100.00 Very High Very High Very High
Dopamine 115 100.00 Very High Very High Very High
Delta opioid receptors 98 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arthritis 99 99.84 Very High Very High Very High
Urological Neuroanatomy 38 99.68 Very High Very High Very High
Pain 1104 99.66 Very High Very High Very High
Inflammatory Pain 630 99.58 Very High Very High Very High
Shock 15 99.50 Very High Very High Very High
Targeted Disruption 49 99.36 Very High Very High Very High
Sperm Disorder 2 99.20 Very High Very High Very High
Bordatella Infection 17 99.08 Very High Very High Very High
Reprotox - General 1 6 99.06 Very High Very High Very High
Ganglion Cysts 40 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Autoradiographic localization of opioid receptor types in the rat small intestine.
Localization (localization) of opioid receptor in small intestine associated with enkephalin and opioid receptor
1) Confidence 0.81 Published 1986 Journal NIDA Res. Monogr. Section Title Doc Link 2828980 Disease Relevance 0 Pain Relevance 0.29
In rat pups, opioid receptor agonists released from casein during digestion such as beta-casomorphins slow down GIT.
Localization (released) of opioid receptor associated with agonist and opioid receptor
2) Confidence 0.80 Published 2005 Journal Biol. Neonate Section Abstract Doc Link 15572871 Disease Relevance 0 Pain Relevance 0.27
The ultrastructural localization of delta-1 opioid receptor in the rat dorsal raphe nucleus was studied by the preembedding avidin-biotin-peroxidase complex technique.
Localization (localization) of delta-1 opioid receptor in raphe nucleus associated with opioid receptor and raphe
3) Confidence 0.80 Published 1997 Journal Synapse Section Abstract Doc Link 9183814 Disease Relevance 0 Pain Relevance 0.21
Ultrastructural localization of delta-1 opioid receptor in the dorsal raphe nucleus of the rat.
Localization (localization) of delta-1 opioid receptor in dorsal associated with opioid receptor and raphe
4) Confidence 0.80 Published 1997 Journal Synapse Section Title Doc Link 9183814 Disease Relevance 0 Pain Relevance 0.24
However, recent studies suggest that short term morphine pretreatment can increase delta opioid receptor-mediated antinociception by promoting the translocation of delta opioid receptor to the cell surface.
Localization (translocation) of delta opioid receptor associated with antinociception, opioid receptor and morphine
5) Confidence 0.76 Published 2006 Journal Neuroscience Section Abstract Doc Link 16716526 Disease Relevance 0 Pain Relevance 1.40
The impairment of both opioid receptor subtypes suggests that opiate systems, like dopaminergic systems, are involved in the neurochemical changes observed in the striatum after transient forebrain ischemia.
Neg (impairment) Localization (impairment) of opioid receptor in forebrain associated with ischemia, opiate and opioid receptor
6) Confidence 0.73 Published 1991 Journal Brain Res. Section Abstract Doc Link 1649667 Disease Relevance 0.30 Pain Relevance 0.58
Delta opioid receptor agonists produce only a moderate degree of antinociception, possibly reflecting the predominantly intracellular location of delta opioid receptor.
Localization (location) of delta opioid receptor associated with antinociception, agonist and opioid receptor
7) Confidence 0.71 Published 2006 Journal Neuroscience Section Abstract Doc Link 16716526 Disease Relevance 0 Pain Relevance 1.11
Dopamine antagonists increased opioid action, an action that may depend more on the increased release of endogenous opioids than on supersensitivity of the opioid receptor.
Localization (release) of opioid receptor associated with dopamine, antagonist, endogenous opioid, opioid receptor and opioid
8) Confidence 0.71 Published 2003 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 14565539 Disease Relevance 0 Pain Relevance 0.82
However, few data exist regarding delta opioid receptor expression and localization in such conditions.
Localization (localization) of opioid receptor associated with opioid receptor
9) Confidence 0.71 Published 2003 Journal Pain Section Abstract Doc Link 12507715 Disease Relevance 0.50 Pain Relevance 0.68
The results suggest a relationship between social activity and opioid peptide release during social contact.
Localization (release) of opioid peptide associated with opioid
10) Confidence 0.71 Published 1999 Journal Brain Res. Section Abstract Doc Link 10350555 Disease Relevance 0 Pain Relevance 1.14
Increased social activity seems to be accompanied by elevated opioid peptide release in distinct brain areas after morphine treatment during juvenile isolation.
Localization (release) of opioid peptide in juvenile associated with opioid and morphine
11) Confidence 0.71 Published 1999 Journal Brain Res. Section Abstract Doc Link 10350555 Disease Relevance 0 Pain Relevance 1.11
Effect of mitragynine, derived from Thai folk medicine, on gastric acid secretion through opioid receptor in anesthetized rats.
Localization (secretion) of opioid receptor associated with opioid receptor
12) Confidence 0.71 Published 2002 Journal Eur. J. Pharmacol. Section Title Doc Link 12044808 Disease Relevance 0 Pain Relevance 0.67
Hydrolysis of casein accelerates gastrointestinal transit via reduction of opioid receptor agonists released from casein in rats.
Localization (released) of opioid receptor associated with narcan, agonist and opioid receptor
13) Confidence 0.70 Published 2005 Journal Biol. Neonate Section Title Doc Link 15572871 Disease Relevance 0 Pain Relevance 0.33
At the electron microscopic level, however, delta-1 opioid receptor immunoreaction products were found to be localized specifically on the postsynaptic membrane of dendrites, dense-cored vesicles, and the surface of the small, clear vesicles in axon terminals with strong immunoreactivity.
Localization (localized) of delta-1 opioid receptor in vesicles associated with opioid receptor
14) Confidence 0.70 Published 1997 Journal Synapse Section Abstract Doc Link 9183814 Disease Relevance 0 Pain Relevance 0.21
The present study showed that delta-1 opioid receptor in the dorsal raphe nucleus is mostly localized on postsynaptic membrane; the main function of the delta-1 receptor in the dorsal raphe nucleus is to receive signals from the opioid-containing axon terminals through synapses.
Localization (localized) of delta-1 opioid receptor in raphe nucleus associated with opioid receptor, opioid and raphe
15) Confidence 0.70 Published 1997 Journal Synapse Section Abstract Doc Link 9183814 Disease Relevance 0 Pain Relevance 0.32
We investigated the effects of centrally injected opioid receptor agonists on gastric acid secretion in the perfused stomach of urethane-anesthetized rats.
Localization (secretion) of opioid receptor in stomach associated with agonist and opioid receptor
16) Confidence 0.68 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11343688 Disease Relevance 0 Pain Relevance 0.82
The recognition of distinct opioid receptor types which may be differentially involved in the control of motility, acid and electrolyte secretion in the GI tract presently focuses the attention of researchers in this field on the identification of receptor-type-selective opioid agonists in order to free these clinically extremely useful drugs from side effects.
Localization (secretion) of opioid receptor associated with mu agonist and opioid receptor
17) Confidence 0.67 Published 1990 Journal Dig Dis Section Abstract Doc Link 2176937 Disease Relevance 0 Pain Relevance 0.48
While all 3 opioid receptor subtypes could sometimes be localized within the same brain area, their precise distribution within the region often varied widely.
Localization (localized) of opioid receptor in brain associated with opioid receptor
18) Confidence 0.64 Published 1987 Journal J. Neurosci. Section Abstract Doc Link 3039080 Disease Relevance 0.10 Pain Relevance 0.85
[Advances in the research of opioid receptor and ion channels of dorsal root ganglion neurons].
Localization (research) of opioid receptor in neurons associated with ganglion cysts, root ganglion neuron and opioid receptor
19) Confidence 0.63 Published 1997 Journal Sheng Li Ke Xue Jin Zhan Section Title Doc Link 11038680 Disease Relevance 0.10 Pain Relevance 0.63
Technical aspects of opioid receptor localization: detection of opioid receptor proteins by immunocytochemistry or with a biotinylated dynorphin analog.
Localization (localization) of opioid receptor associated with dynorphin and opioid receptor
20) Confidence 0.63 Published 1994 Journal J. Neurosci. Methods Section Title Doc Link 8051952 Disease Relevance 0 Pain Relevance 0.49

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox