INT125709

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Context Info
Confidence 0.27
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.17
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col3a1) extracellular region (Col3a1)
Anatomy Link Frequency
epithelial cell 2
bladders 2
Col3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 9 100.00 Very High Very High Very High
methotrexate 55 94.80 High High
intrathecal 1 90.88 High High
fibrosis 18 90.52 High High
qutenza 1 88.92 High High
bradykinin 1 87.92 High High
Spinal cord 1 75.00 Quite High
Central nervous system 1 68.08 Quite High
cytokine 32 50.00 Quite Low
Dopamine 6 40.08 Quite Low
Disease Link Frequency Relevance Heat
Sepsis 26 100.00 Very High Very High Very High
Apoptosis 13 100.00 Very High Very High Very High
Adhesions 9 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 39 99.96 Very High Very High Very High
Stress 94 98.56 Very High Very High Very High
Pulmonary Edema 7 98.20 Very High Very High Very High
Coronary Heart Disease 2 97.48 Very High Very High Very High
Heart Rate Under Development 25 97.04 Very High Very High Very High
Hypertension 33 95.96 Very High Very High Very High
Urinary Dysfunction 4 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphometric studies on animal or human bladder strips have demonstrated an increased expression of proteolytic enzymes and endogenous tissue inhibitors of metalloproteinases (MMP-1) and type III collagen mRNA in hypocompliant neurogenic bladders.
Positive_regulation (increased) of Gene_expression (expression) of type III collagen mRNA in bladders associated with metalloproteinase
1) Confidence 0.27 Published 2004 Journal Prog. Urol. Section Abstract Doc Link 15776894 Disease Relevance 0.47 Pain Relevance 0.26
The expression of collagen type III also significantly increased according to the number of days of stress exposure.

3.

Positive_regulation (increased) of Gene_expression (expression) of collagen type III associated with stress
2) Confidence 0.21 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855479 Disease Relevance 1.05 Pain Relevance 0
As a result, the EAM60 group rats showed significantly increased expression of collagen type I and III, mainly type I, in myocardial interstitium, compared with the control group.
Positive_regulation (increased) of Gene_expression (expression) of collagen type I and III
3) Confidence 0.14 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768010 Disease Relevance 0.51 Pain Relevance 0.35
Collagen type I and type III mRNA expression levels in the infarcted area of AdV.SDF-1 group, control group and AdV.LacZ group increased obviously compared to that of sham-operated rats.
Positive_regulation (increased) of Gene_expression (expression) of Collagen type I and type III mRNA
4) Confidence 0.13 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.27 Pain Relevance 0
Furthermore, the expression of collagen type I and type III mRNA, and collagen accumulation in the infarcted area was lower, which was associated with decreased TGF-?
Positive_regulation (accumulation) of Gene_expression (expression) of collagen type I and type III mRNA
5) Confidence 0.13 Published 2009 Journal Mol Biol Rep Section Abstract Doc Link PMC2831180 Disease Relevance 0.44 Pain Relevance 0
, caspase-3, type III procollagen (PCIII), intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) mRNA expressions in lung tissue, as well as lung and distal organ epithelial cell apoptosis in an experimental model of sepsis-induced ALI.


Positive_regulation (induced) of Gene_expression (expressions) of type III procollagen in epithelial cell associated with adult respiratory distress syndrome, apoptosis, sepsis and adhesions
6) Confidence 0.06 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.75 Pain Relevance 0
Preclinical data show that, as with captopril, zofenopril significantly increases the myocardial expression of collagen type III and normalized the collagen type I/III ratio, thus preventing myocardial hypertrophy in spontaneous hypertensive rats.
Positive_regulation (increases) of Gene_expression (expression) of collagen type III associated with hypertension and coronary heart disease
7) Confidence 0.05 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994025 Disease Relevance 0.68 Pain Relevance 0.04

General Comments

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