INT125727

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.04
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (FGF23) extracellular space (FGF23) extracellular region (FGF23)
Anatomy Link Frequency
fibroblast 2
fat pad 1
FGF23 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 4 99.80 Very High Very High Very High
Pain 4 92.96 High High
Opioid 1 12.84 Low Low
Glutamate 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rickets 22 99.74 Very High Very High Very High
Cleidocranial Dysplasia 2 99.70 Very High Very High Very High
Cancer 11 98.92 Very High Very High Very High
Peripheral Arterial Disease 1 97.88 Very High Very High Very High
Congenital Anomalies 2 95.60 Very High Very High Very High
Pain 4 92.96 High High
Muscle Weakness 1 92.72 High High
Hypophosphatemia 5 91.60 High High
Targeted Disruption 3 81.24 Quite High
Muscle Disease 1 79.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This phenotype parallels that of patients with tumor induced osteomalacia (TIO), X-linked hypophosphatemic rickets (XLH), and fibrous dysplasia (FD), in whom elevated serum FGF23 levels are often observed.
Positive_regulation (elevated) of FGF23 associated with rickets, cancer and cleidocranial dysplasia
1) Confidence 0.69 Published 2005 Journal Ther Apher Dial Section Abstract Doc Link 16076372 Disease Relevance 0.84 Pain Relevance 0.09
Oncogenic osteomalacia: diagnostic importance of fibroblast growth factor 23 and F-18 fluorodeoxyglucose PET/CT scan for the diagnosis and follow-up in one case.
Positive_regulation (importance) of fibroblast growth factor 23 in fibroblast associated with rickets
2) Confidence 0.50 Published 2005 Journal Bone Section Title Doc Link 15777669 Disease Relevance 0.72 Pain Relevance 0.14
Several FGFR isoforms that potentially mediate the activity of FGF23 have been implicated.
Positive_regulation (mediate) of FGF23
3) Confidence 0.50 Published 2005 Journal Ther Apher Dial Section Abstract Doc Link 16076372 Disease Relevance 0.76 Pain Relevance 0.08
Serum FGF23 concentration was elevated and MRI identified a 2 cm tumour within Hoffa's fat pad of the left knee.
Positive_regulation (elevated) of FGF23 in fat pad associated with cancer, peripheral arterial disease and imagery
4) Confidence 0.47 Published 2008 Journal Eur. J. Endocrinol. Section Abstract Doc Link 18230836 Disease Relevance 1.43 Pain Relevance 0.22
PHEX has no known natural substrate, although it has been reported that it may cleave FGF-23, a member of the fibroblast growth factor family that inhibits renal tubular phosphate transport [12].
Positive_regulation (cleave) of FGF-23 in fibroblast
5) Confidence 0.04 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2259306 Disease Relevance 0.29 Pain Relevance 0

General Comments

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