INT125735

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 1.34
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx7) cell morphogenesis (P2rx7) mitochondrion organization (P2rx7)
protein complex (P2rx7) transmembrane transport (P2rx7) cytoplasm (P2rx7)
Anatomy Link Frequency
sensory neurons 1
C8-B4 1
P2rx7 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 3 100.00 Very High Very High Very High
neuralgia 2 100.00 Very High Very High Very High
Calcitonin gene-related peptide 9 99.84 Very High Very High Very High
Inflammation 4 99.24 Very High Very High Very High
Neuropathic pain 11 98.56 Very High Very High Very High
Migraine 2 95.88 Very High Very High Very High
Pain 4 95.52 Very High Very High Very High
cytokine 2 90.16 High High
medulla 1 83.92 Quite High
Trigeminal ganglion neurons 1 69.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 99.24 Very High Very High Very High
Neuropathic Pain 15 98.56 Very High Very High Very High
Headache 2 95.88 Very High Very High Very High
Pain 4 95.52 Very High Very High Very High
Nociception 2 90.44 High High
Hypersensitivity 1 78.96 Quite High
Targeted Disruption 3 73.64 Quite High
Ganglion Cysts 1 69.48 Quite High
Myelodysplastic Syndromes 2 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain.
Transcription (Disruption) of P2X7 purinoceptor gene associated with neuralgia, inflammation and neuropathic pain
1) Confidence 0.62 Published 2005 Journal Pain Section Title Doc Link 15777864 Disease Relevance 0.80 Pain Relevance 0.67
We found significant amounts of P2X3, P2X4, P2X6, and P2X7 transcripts in resting C8-B4 cells with the following relative expression levels: P2X7 > P2X4 > P2X3 > P2X6.
Transcription (transcripts) of P2X7 in C8-B4
2) Confidence 0.22 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.06
Mechanisms mediating the enhanced gene transcription of P2X3 receptor by calcitonin gene-related peptide in trigeminal sensory neurons.
Transcription (transcription) of P2X3 receptor in sensory neurons associated with nociceptor and calcitonin gene-related peptide
3) Confidence 0.03 Published 2008 Journal J. Biol. Chem. Section Title Doc Link 18460469 Disease Relevance 0.53 Pain Relevance 0.86

General Comments

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