INT12575

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Context Info
Confidence 0.59
First Reported 1984
Last Reported 2010
Negated 2
Speculated 8
Reported most in Abstract
Documents 33
Total Number 42
Disease Relevance 17.70
Pain Relevance 18.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Hpse) extracellular region (Hpse) cell adhesion (Hpse)
nucleus (Hpse) carbohydrate metabolic process (Hpse) lysosome (Hpse)
Anatomy Link Frequency
pituitary 4
spinal cord 2
plasma 1
nucleus 1
amygdala 1
Hpse (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 82 100.00 Very High Very High Very High
narcan 28 100.00 Very High Very High Very High
cocaine 25 100.00 Very High Very High Very High
withdrawal 23 100.00 Very High Very High Very High
tolerance 15 100.00 Very High Very High Very High
Analgesic 12 100.00 Very High Very High Very High
analgesia 7 100.00 Very High Very High Very High
antidepressant 67 99.96 Very High Very High Very High
Dopamine 19 99.92 Very High Very High Very High
opiate 8 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 837 99.82 Very High Very High Very High
Rheumatoid Arthritis 170 99.60 Very High Very High Very High
Pain 10 99.28 Very High Very High Very High
Multiple Sclerosis 396 98.62 Very High Very High Very High
Metabolic Syndrome 28 97.48 Very High Very High Very High
Metastasis 4 97.36 Very High Very High Very High
Diabetes Mellitus 11 96.96 Very High Very High Very High
Pressure And Volume Under Development 55 96.56 Very High Very High Very High
Cancer 36 96.20 Very High Very High Very High
Disease 130 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: The present study investigated the effects of manipulations known to affect HPA activity on morphine-induced conditioned place preference (CPP) in male LEW, F344, and Sprague-Dawley (SD) rats.
Regulation (affect) of HPA
1) Confidence 0.59 Published 2006 Journal Psychopharmacology (Berl.) Section Body Doc Link 17016707 Disease Relevance 0.09 Pain Relevance 0
In the present study we investigated the analgesic effect of verapamil, diltiazem and nimodipine in intact and adrenalectomized (ADX) male rats and also measured the effect of these drugs on HPA function.
Regulation (effect) of HPA associated with analgesic
2) Confidence 0.54 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19171163 Disease Relevance 0.18 Pain Relevance 0.40
Indomethacin did not change basal plasma ACTH and corticosterone levels, indicating that prostaglandins are not involved in basal regulation of the HPA activity.
Regulation (regulation) of HPA in plasma
3) Confidence 0.53 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10574467 Disease Relevance 0.46 Pain Relevance 0.37
Naloxone did not affect resting HPA activity but reduced markedly the stress-induced release of corticotrophin.
Neg (not) Regulation (affect) of HPA associated with stress and narcan
4) Confidence 0.49 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2821423 Disease Relevance 0.36 Pain Relevance 0.50
This suggests an interaction between presynaptic opioid and alpha 2-receptors in regulation of the HPA function.
Regulation (regulation) of HPA associated with opioid
5) Confidence 0.47 Published 1996 Journal Folia Med Cracov Section Abstract Doc Link 9269123 Disease Relevance 0 Pain Relevance 1.65
We examined the effect of nifedipine on morphine-induced analgesia in intact and adrenalectomized (ADX) rats and on HPA activity induced by morphine.
Spec (examined) Regulation (effect) of HPA associated with analgesia and morphine
6) Confidence 0.45 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 16111739 Disease Relevance 0.08 Pain Relevance 1.10
We examined the effect of nifedipine on morphine analgesic tolerance in intact and adrenalectomized (ADX) rats and on HPA activity induced by morphine.
Spec (examined) Regulation (effect) of HPA associated with analgesic, tolerance and morphine
7) Confidence 0.45 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15894073 Disease Relevance 0.07 Pain Relevance 1.31
These data suggest that both mu- and delta-opioid receptors are involved in the regulation of HPA activity under physiological conditions and during opiate abuse.
Regulation (regulation) of HPA associated with opiate and delta opioid receptors
8) Confidence 0.40 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1663037 Disease Relevance 0 Pain Relevance 0.69
The results of this study demonstrate that significant opiate receptor control of HPA function can be demonstrated early in postnatal development, even before the onset of the stress-hyporesponsive period.
Regulation (control) of HPA associated with stress and opiate
9) Confidence 0.36 Published 1991 Journal Endocrinology Section Abstract Doc Link 1649751 Disease Relevance 0.19 Pain Relevance 0.86
The results suggest the opioid peptides and their receptors play a major role in the regulation of HPA function.
Regulation (regulation) of HPA associated with opioid
10) Confidence 0.35 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6328347 Disease Relevance 0.12 Pain Relevance 1.29
Inhibition of prostaglandins synthesis by indomethacin significantly diminished the vasopressin-induced HPA response under both basal and social stress conditions, whereas it did affect the CRH-elicited HPA stimulation under both these circumstances.
Regulation (affect) of HPA associated with stress
11) Confidence 0.34 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10574467 Disease Relevance 0.41 Pain Relevance 0.34
The present results suggest an important stimulatory role for DA in regulation of HPA activity, and a role for both DA and 5-HT in the adrenocortical stimulation by cocaine.
Regulation (regulation) of HPA associated with dopamine and cocaine
12) Confidence 0.33 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1671094 Disease Relevance 0 Pain Relevance 0.99
The dosage of HEP for rats in this study was determined based on the dosage used in clinical trials and calculated using the dose conversion table between human and rats.
Regulation (calculated) of HEP
13) Confidence 0.32 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193542 Disease Relevance 0 Pain Relevance 0.06
We analyzed the ability of buprenorphine to prevent the effects of experimental surgery on HPA activation (plasma corticosterone levels), NK activity and lung diffusion of the NK sensitive tumor MADB106.
Regulation (effects) of HPA in lung associated with cancer and buprenorphine
14) Confidence 0.27 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17291715 Disease Relevance 0.42 Pain Relevance 0.94
In the present study we investigated the analgesic effect of nifedipine in intact and adrenalectomized (ADX) male rats and we also measured the effect of nifedipine on HPA function.
Regulation (effect) of HPA associated with analgesic
15) Confidence 0.24 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 17112573 Disease Relevance 0.18 Pain Relevance 0.35
Experiments with laboratory rats were performed to test whether psychoactive substances (among them clinically effective antidepressants) influence circadian HPA activity.
Spec (whether) Regulation (influence) of HPA associated with antidepressant
16) Confidence 0.24 Published 1985 Journal Psychoneuroendocrinology Section Abstract Doc Link 3878973 Disease Relevance 0 Pain Relevance 0.14
We also evaluated the effect of this drug on HPA activity induced by naloxone.
Regulation (effect) of HPA associated with narcan
17) Confidence 0.21 Published 2008 Journal Horm Behav Section Abstract Doc Link 18177874 Disease Relevance 0.09 Pain Relevance 0.95
Both opioids and calcium channel blockers could affect hypothalamic-pituitary-adrenal (HPA) axis function.
Regulation (affect) of HPA in pituitary associated with calcium channel and opioid
18) Confidence 0.21 Published 2008 Journal Horm Behav Section Abstract Doc Link 18177874 Disease Relevance 0.09 Pain Relevance 0.73
The control of hypothalamic-pituitary-adrenocortical (HPA) activity by opioids seems to involve stimulatory and inhibitory pathways.
Regulation (control) of HPA in pituitary associated with opioid
19) Confidence 0.21 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1663037 Disease Relevance 0 Pain Relevance 0.50
The effects of morphine and naloxone on hypothalamo-pituitary-adrenocortical (HPA) activity and blood pressure were studied in rats in which adrenergic transmission had been impaired pharmacologically.
Regulation (effects) of HPA in blood associated with narcan and morphine
20) Confidence 0.19 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2821423 Disease Relevance 0.12 Pain Relevance 0.25

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