INT125762

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.62
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Pcsk1) extracellular space (Pcsk1) Golgi apparatus (Pcsk1)
Anatomy Link Frequency
PC-3 3
Pcsk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 8 99.44 Very High Very High Very High
Enkephalin 2 99.20 Very High Very High Very High
qutenza 11 98.98 Very High Very High Very High
antagonist 32 88.24 High High
cytokine 10 73.52 Quite High
Spinal cord 14 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
Inflammation 11 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Hippocampus 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 173 99.96 Very High Very High Very High
Body Weight 3 99.70 Very High Very High Very High
Apoptosis 11 97.88 Very High Very High Very High
Hypercalcemia 46 97.60 Very High Very High Very High
Osteoporosis 68 91.32 High High
Prostate Cancer 4 88.56 High High
Targeted Disruption 14 85.40 High High
Stress 22 78.48 Quite High
Reprotox - General 1 52 75.24 Quite High
Motor Neuron Diseases 107 73.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neuropeptide processing profile in mice lacking prohormone convertase-1.
Negative_regulation (lacking) of prohormone convertase-1 associated with neuropeptide
1) Confidence 0.42 Published 2005 Journal Biochemistry Section Title Doc Link 15779921 Disease Relevance 0.44 Pain Relevance 0.55
At the level of individual genes, significant changes in gene expression similarly indicate a reduction of glycolysis (ANGPTL4) and glucose availability (CHGB, SCG5, PCSK1).
Negative_regulation (reduction) of PCSK1
2) Confidence 0.30 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.62 Pain Relevance 0
Subcutaneous injection of either capsaicin or capsazepine (5 mg/kg body weight) in nude mice suppressed PC-3 tumor growth in all tumors investigated and induced apoptosis of tumor cells.
Negative_regulation (suppressed) of PC-3 in PC-3 associated with body weight, qutenza, cancer and apoptosis
3) Confidence 0.21 Published 2006 Journal Apoptosis Section Abstract Doc Link 16374544 Disease Relevance 1.25 Pain Relevance 0.76
Therefore, noggin suppression in the osteolytic cell line PC-3 seems to preserve the bone formation that normally follows bone resorption, as an effect of the “coupling phenomenon”.
Negative_regulation (suppression) of PC-3 in PC-3 associated with hypercalcemia
4) Confidence 0.01 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 1.20 Pain Relevance 0.07
Consistently with previous investigations in parental PC-3 cells [17], RANKL expression was undetectable in PC-3/Fluc, mock and Nog-KD clones.
Negative_regulation (undetectable) of PC-3 in PC-3
5) Confidence 0.01 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 0.11 Pain Relevance 0

General Comments

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