INT125765

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.06
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100b) nucleus (S100b) cytoplasm (S100b)
Anatomy Link Frequency
brain 2
S100b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 1 98.64 Very High Very High Very High
tetrodotoxin 3 92.28 High High
sodium channel 1 91.36 High High
Calcium channel 1 88.00 High High
Gabapentin 2 50.00 Quite Low
Central nervous system 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 2 63.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with gabapentin prevented the upregulation of GFAP, S100B, and NSE in all brain regions of diabetic rats.
Negative_regulation (prevented) of Positive_regulation (upregulation) of S100B in brain
1) Confidence 0.42 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15780189 Disease Relevance 0.06 Pain Relevance 0
In contrast to the pharmacologic manipulations mentioned above, glutamate and alpha-ketoglutarate added at high concentrations to the medium prevented both OGD- and REO-induced S100B outputs.
Negative_regulation (prevented) of Positive_regulation (induced) of S100B associated with glutamate
2) Confidence 0.37 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.40

General Comments

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