INT125767

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.08
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100b) nucleus (S100b) cytoplasm (S100b)
Anatomy Link Frequency
brain 4
astrocytes 4
nerve 2
S100b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 29 99.88 Very High Very High Very High
dorsal root ganglion 36 98.20 Very High Very High Very High
Sciatic nerve 55 96.88 Very High Very High Very High
ischemia 40 92.28 High High
Inflammatory response 23 82.52 Quite High
Inflammatory marker 1 81.40 Quite High
cINOD 6 68.36 Quite High
cerebral cortex 18 67.68 Quite High
nav1.8 6 65.20 Quite High
Inflammation 50 53.04 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 42 98.96 Very High Very High Very High
Ganglion Cysts 36 98.20 Very High Very High Very High
Disease 140 97.28 Very High Very High Very High
Reperfusion Injury 6 93.04 High High
Cv General 4 Under Development 24 92.28 High High
Hypothermia 66 91.04 High High
Nerve Compression Syndromes 31 89.28 High High
Headache 4 87.68 High High
Lewy Body Disease 66 86.84 High High
INFLAMMATION 74 82.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Total and degraded GFAP content and S100B protein expression in different areas of brain tissues significantly increased in diabetic rats compared to control rats.
Positive_regulation (increased) of Gene_expression (expression) of S100B protein in brain
1) Confidence 0.49 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15780189 Disease Relevance 0.08 Pain Relevance 0
RESULTS: During migraine attacks elevated s100b levels could be observed.
Positive_regulation (elevated) of Gene_expression (levels) of s100b
2) Confidence 0.33 Published 2009 Journal Headache Section Body Doc Link 18783450 Disease Relevance 0.09 Pain Relevance 0
This was based on our demonstration that activated microglia overexpressing interleukin-1 (IL-1), a potent immune response-generating cytokine, and activated astrocytes overexpressing S100B, a cytokine that promotes excessive neurite growth, in Alzheimer’s disease (Griffin et al 1989).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of S100B in astrocytes associated with disease and cytokine
3) Confidence 0.32 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656298 Disease Relevance 0.98 Pain Relevance 0.28
Interestingly, although s100B expression was strong in nerve cultures, it was still stronger in DRG cultures (Fig. 5E).


Positive_regulation (strong) of Gene_expression (expression) of s100B in nerve associated with dorsal root ganglion
4) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.53 Pain Relevance 0.60
This was based on our demonstration that activated microglia overexpressing interleukin-1 (IL-1), a potent immune response-generating cytokine, and activated astrocytes overexpressing S100B, a cytokine that promotes excessive neurite growth, in Alzheimer’s disease (Griffin et al 1989).
Positive_regulation (activated) of Gene_expression (overexpressing) of S100B in astrocytes associated with disease and cytokine
5) Confidence 0.23 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656298 Disease Relevance 0.99 Pain Relevance 0.28
Concerning reliable biochemical markers of brain tissue damage, increased serum levels of the low molecular weight protein S100B have been reported after cardiac arrest correlating with neurological complications.
Positive_regulation (increased) of Gene_expression (levels) of protein S100B in brain associated with myocardial infarction
6) Confidence 0.02 Published 2010 Journal Crit Care Section Body Doc Link PMC2875536 Disease Relevance 1.42 Pain Relevance 0.36

General Comments

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