INT12577

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Context Info
Confidence 0.57
First Reported 1991
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.45
Pain Relevance 4.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neutrophil 1
H7 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 16 100.00 Very High Very High Very High
Kinase C inhibitor 2 100.00 Very High Very High Very High
analgesia 9 99.22 Very High Very High Very High
Morphine 5 98.86 Very High Very High Very High
antagonist 4 97.52 Very High Very High Very High
tetrodotoxin 5 95.78 Very High Very High Very High
Enkephalin 9 95.26 Very High Very High Very High
Cholecystokinin 2 93.32 High High
Dynorphin 2 91.28 High High
bradykinin 2 90.20 High High
Disease Link Frequency Relevance Heat
Cognitive Disorder 18 95.88 Very High Very High Very High
Depression 1 85.36 High High
Targeted Disruption 10 82.32 Quite High
Pre-term Labor 2 70.00 Quite High
Disease 30 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 6 5.00 Very Low Very Low Very Low
Neurological Disease 4 5.00 Very Low Very Low Very Low
Amnesia 4 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The stimulation of the iodide organification, induced by norepinephrine, was inhibited by omission of calcium from the medium and by protein kinase C inhibitors such as H 7, quercetin and trifluoperazine, but not by W-7, a calmodulin antagonist.
Negative_regulation (inhibitors) of H 7 associated with antagonist and kinase c inhibitor
1) Confidence 0.57 Published 1991 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 1688097 Disease Relevance 0 Pain Relevance 0.43
MENK induced O2- release was associated with a dose-dependent increase of diacylglycerol (DAG) concentration and protein-kinase C (PKC) translocation to the neutrophil membranes, with an increase of cytosolic Ca++, and could be abolished by H7, a PKC inhibitor.
Negative_regulation (inhibitor) of H7 in neutrophil associated with kinase c and enkephalin
2) Confidence 0.09 Published 1996 Journal Neuropeptides Section Abstract Doc Link 8771562 Disease Relevance 0 Pain Relevance 0.83
These results indicated a partial involvement of Na(+)-entry through TTX-sensitive Na(+)-channels. 3) Endothelin-induced contractions were effectively depressed by NCDC, an inhibitor of phospholipase C, suggesting the involvement of PI-turnover in the contraction. 4) Protein kinase inhibitors such as H-7 and H-8 effectively depressed endothelin-induced contractions.
Negative_regulation (inhibitors) of H-7 associated with tetrodotoxin
3) Confidence 0.03 Published 1991 Journal Nippon Seirigaku Zasshi Section Abstract Doc Link 1649917 Disease Relevance 0.09 Pain Relevance 0.56
Although IRAP was cloned more than a decade ago, the first and only specific, high affinity inhibitors of IRAP that are used to investigate the physiological roles of the enzyme are the peptides Ang IV and LVV-H7.
Negative_regulation (inhibitors) of LVV-H7
4) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.25 Pain Relevance 0.31
The two archetypal competitive inhibitors of IRAP are the peptides Ang IV (VYIHPF) and LVV-H7 (LVVYPWTQRF), with Ki values of 113 nM and 845 nM, respectively [21].
Negative_regulation (inhibitors) of LVV-H7
5) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.12 Pain Relevance 0.23
The inhibitory effects of the 60-Hz magnetic field on morphine-induced analgesia were significantly reduced by the PKC inhibitors, H-7 and H-9, and significantly enhanced by the PKC activator, SC-9.
Negative_regulation (inhibitors) of H-7 associated with kinase c, analgesia and morphine
6) Confidence 0.00 Published 1991 Journal Brain Res. Section Abstract Doc Link 1933319 Disease Relevance 0 Pain Relevance 1.85

General Comments

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