INT125773

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Context Info
Confidence 0.53
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.35
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
neurons 1
astrocytes 1
articular cartilage 1
Serpine1 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 1 84.52 Quite High
Neuropathic pain 1 77.32 Quite High
Peripheral nerve injury 1 75.00 Quite High
Root ganglion neuron 1 75.00 Quite High
neuralgia 2 25.00 Low Low
Central nervous system 9 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 27 98.32 Very High Very High Very High
Glioma 4 96.32 Very High Very High Very High
Injury 5 96.16 Very High Very High Very High
Middle Cerebral Artery Infarction 17 90.80 High High
Melanoma 5 88.80 High High
Metastasis 12 88.08 High High
Temporomandibular Joint Syndrome 1 83.32 Quite High
Cancer 56 83.12 Quite High
Neuropathic Pain 1 77.32 Quite High
Osteolysis 1 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We employed laser capture microdissection (LCM) combined with RT-PCR to measure tPA and PAI-1 mRNA levels in astrocytes in the IBZ (Fig. 5a) after stroke with or without MSC treatment.
Transcription (levels) of PAI in astrocytes associated with stroke
1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.78 Pain Relevance 0
The right joints of these animals were harvested and processed for the examination of mRNA expression of uPA and PAI-1 in articular cartilage using in situ hybridization techniques.
Transcription (expression) of PAI-1 in articular cartilage
2) Confidence 0.25 Published 2005 Journal Chin. Med. J. Section Body Doc Link 15978208 Disease Relevance 0.08 Pain Relevance 0
This effect was due to blocked phosphorylation of SMADs leading to reduced transcription of PAI-1 and VEGF which are key mediators in cell invasion and neoangiogenesis [95].
Transcription (transcription) of PAI-1
3) Confidence 0.19 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 0.98 Pain Relevance 0
The precise expression patterns of PAI-1 and PAI-2 mRNA at 3 days after axotomy revealed that PAI-1 mRNA was observed in predominantly small neurons, while much of the PAI-2 mRNA was expressed in large neurons.
Transcription (observed) of PAI-1 in neurons
4) Confidence 0.10 Published 2005 Journal Neuroscience Section Abstract Doc Link 15780477 Disease Relevance 0.50 Pain Relevance 0.19

General Comments

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