INT125775

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 3.81
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinb2) extracellular region (Serpinb2) Golgi apparatus (Serpinb2)
cytoplasm (Serpinb2)
Anatomy Link Frequency
neurons 2
sciatic nerve 1
extracellular matrix 1
DRG 1
Serpinb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 4 99.12 Very High Very High Very High
Neuropathic pain 4 96.68 Very High Very High Very High
depression 3 85.64 High High
Peripheral nerve injury 4 75.00 Quite High
Root ganglion neuron 4 75.00 Quite High
metalloproteinase 30 59.00 Quite High
Inflammation 26 48.00 Quite Low
neuralgia 8 25.00 Low Low
cytokine 12 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 51 100.00 Very High Very High Very High
Injury 19 99.24 Very High Very High Very High
Neuropathic Pain 4 96.68 Very High Very High Very High
Convalescence 17 91.76 High High
Pulmonary Hypertension 105 91.04 High High
Cardiomegaly 12 86.76 High High
Depression 3 85.64 High High
Congenital Anomalies 9 85.04 High High
Nervous System Injury 8 75.00 Quite High
Ganglion Cysts 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An upregulation of tissue plasminogen activator (plat) by 3.74 ± 0.83 and plasminogen activator inhibitor-2 (Serpinb2) by 2.68 ± 0.83 foldwith MCT treatment was also observed.
Positive_regulation (upregulation) of plasminogen activator inhibitor-2
1) Confidence 0.36 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.41 Pain Relevance 0.03
An upregulation of tissue plasminogen activator (plat) by 3.74 ± 0.83 and plasminogen activator inhibitor-2 (Serpinb2) by 2.68 ± 0.83 foldwith MCT treatment was also observed.
Positive_regulation (upregulation) of Serpinb2
2) Confidence 0.36 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.41 Pain Relevance 0.03
Micro-arrays and subsequent confirmation with real time PCR demonstrated upregulation of several extracellular matrix regulation and adhesion genes, such as matrixmetalloproteases (MMP) 2, 8, 9, 10, 11, 12, 20, Icam, Itgax, Plat and serpinb2.
Positive_regulation (upregulation) of serpinb2 in extracellular matrix associated with adhesions
3) Confidence 0.36 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1291406 Disease Relevance 0.85 Pain Relevance 0.04
Double-labeling analysis of these mRNAs with activated transcription factor 3, known as an injury marker, revealed that most PAI-1 and PAI-2 mRNAs was induced in injured neurons.
Positive_regulation (induced) of PAI-2 in neurons associated with injury
4) Confidence 0.05 Published 2005 Journal Neuroscience Section Abstract Doc Link 15780477 Disease Relevance 0.49 Pain Relevance 0.18
The results showed that both PAI-1 and PAI-2 mRNA were up-regulated in DRG neurons within 1 day, and peaked at 1-3 days, after injury.
Positive_regulation (regulated) of PAI-2 mRNA in DRG associated with injury
5) Confidence 0.05 Published 2005 Journal Neuroscience Section Abstract Doc Link 15780477 Disease Relevance 0.49 Pain Relevance 0.21
The precise expression patterns of PAI-1 and PAI-2 mRNA at 3 days after axotomy revealed that PAI-1 mRNA was observed in predominantly small neurons, while much of the PAI-2 mRNA was expressed in large neurons.
Positive_regulation (much) of PAI-2 mRNA in neurons
6) Confidence 0.04 Published 2005 Journal Neuroscience Section Abstract Doc Link 15780477 Disease Relevance 0.50 Pain Relevance 0.19
From these transcripts, those for which abundance decreased drastically were EGR3, CD69, LCK, BCL2 and CD28, while IL1R2, SERPINB2, CLU and TIMP1 increased by more than 1.7 fold (Table 2).
Positive_regulation (increased) of SERPINB2
7) Confidence 0.02 Published 2010 Journal Immun Ageing Section Body Doc Link PMC2933667 Disease Relevance 0.26 Pain Relevance 0
Here we examined whether the plasminogen activator inhibitor-1 and -2 (PAI-1 and PAI-2) mRNA, endogenous inhibitors of tPA and uPA, are induced in the DRG following sciatic nerve transection.
Spec (whether) Positive_regulation (induced) of PAI-2 in sciatic nerve associated with sciatic nerve
8) Confidence 0.02 Published 2005 Journal Neuroscience Section Abstract Doc Link 15780477 Disease Relevance 0.40 Pain Relevance 0.22

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