INT125796

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.95
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
Anatomy Link Frequency
macrophage 2
cleavage 2
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 15 100.00 Very High Very High Very High
Inflammation 14 99.80 Very High Very High Very High
cINOD 8 99.60 Very High Very High Very High
agonist 2 99.20 Very High Very High Very High
Central nervous system 5 98.00 Very High Very High Very High
anesthesia 3 83.80 Quite High
Pain 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 108 100.00 Very High Very High Very High
INFLAMMATION 16 99.80 Very High Very High Very High
Disease 114 99.76 Very High Very High Very High
Systemic Lupus Erythematosus 5 98.32 Very High Very High Very High
Infection 6 97.84 Very High Very High Very High
Apoptosis 1 94.68 High High
Immunization 1 94.40 High High
Amyloid Plaque 73 91.64 High High
Aging 3 89.36 High High
Neurodegenerative Disease 16 88.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the previous reports, changes in APP expression or ?
Regulation (changes) of Gene_expression (expression) of APP
1) Confidence 0.59 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.24 Pain Relevance 0
His research on the neuropathogenesis of Alzheimer's disease has focused primarily on the molecular mechanisms underlying beta-amyloid precursor protein processing and beta-amyloid protein production, especially regarding regulation of the gamma-secretase complex.Additionally, his work has addressed the role of presenilin-related apoptosis in Alzheimer's disease.
Regulation (underlying) of Gene_expression (production) of beta-amyloid protein associated with alzheimer's dementia, apoptosis and disease
2) Confidence 0.52 Published 2005 Journal J. Mol. Neurosci. Section Abstract Doc Link 15781967 Disease Relevance 0.67 Pain Relevance 0.08
In addition, non-steroidal anti-inflammatory drugs (NSAIDs) and HMG-CoA reductase inhibitors (statins), two classes of drugs reported to affect APP processing and Abeta formation in Alzheimer's disease, have been evaluated for their capacity to inhibit macrophage activation evoked by platelet phagocytosis.
Regulation (affect) of Gene_expression (processing) of APP in macrophage associated with inflammation, cinod, disease and abeta
3) Confidence 0.39 Published 2006 Journal Cardiovascular & hematological disorders drug targets Section Abstract Doc Link 16724933 Disease Relevance 0.99 Pain Relevance 0.49
-secretase-mediated APP cleavage was not affected by a low concentration of H2O2 (from 1 to 100 ?
Neg (not) Regulation (affected) of Gene_expression (cleavage) of APP in cleavage
4) Confidence 0.38 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.31 Pain Relevance 0.03
Net effects on sAPP proteins differ from what is seen in MS, cerebral SLE and CNS infections, since AD patients have unaltered or even elevated CSF levels of ?
Regulation (effects) of Gene_expression (proteins) of sAPP associated with central nervous system, disease, systemic lupus erythematosus and infection
5) Confidence 0.35 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2902447 Disease Relevance 2.48 Pain Relevance 0.24
may be indicators of altered APP expression and/or metabolism.
Regulation (altered) of Gene_expression (expression) of APP
6) Confidence 0.27 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2945639 Disease Relevance 0.69 Pain Relevance 0
In addition, 25OH treatment did not alter the overall distribution of APP-GFP expressed alone (Figure 4A), and no noticeable changes in the subcellular localization of BACE1-GFP were observed with OSBP1 co-expression (data not shown).
Neg (not) Regulation (alter) of Gene_expression (expressed) of APP-GFP
7) Confidence 0.26 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
Peroxisome proliferator activated receptor-gamma agonists and selected NSAIDs may be suitable to modulate both Abeta production and inflammatory activation.
Regulation (modulate) of Gene_expression (production) of Abeta associated with inflammation, cinod, agonist and abeta
8) Confidence 0.20 Published 2006 Journal Drugs Section Abstract Doc Link 17112302 Disease Relevance 0.57 Pain Relevance 0.56

General Comments

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