INT125800

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 5.40
Pain Relevance 1.47

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isomerase activity (P4HB) small molecule metabolic process (P4HB) extracellular region (P4HB)
endoplasmic reticulum (P4HB) plasma membrane (P4HB) lipid metabolic process (P4HB)
Anatomy Link Frequency
plasma 1
CSF 1
immune system 1
P4HB (Homo sapiens)
P4HB - P55S (1)
Pain Link Frequency Relevance Heat
Inflammation 112 93.16 High High
Inflammatory mediators 2 89.52 High High
cytokine 144 85.20 High High
chemokine 4 81.24 Quite High
headache 3 75.24 Quite High
Crohn's disease 2 66.56 Quite High
psoriasis 152 66.40 Quite High
rheumatoid arthritis 18 65.76 Quite High
Infliximab 60 55.04 Quite High
Etanercept 86 51.36 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 10 99.66 Very High Very High Very High
Meningitis 3 97.40 Very High Very High Very High
INFLAMMATION 116 93.16 High High
Dermatitis 4 92.64 High High
Apoptosis 14 91.56 High High
Obesity 38 91.44 High High
Pancreatitis 3 89.32 High High
Viral Meningitis 1 87.60 High High
Appetite Loss 2 86.28 High High
Infection 27 84.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Western blotting for HIV antibodies were positive for p24, p40 and p55, whereas that for gp 41 was negative in serum and CSF, suggesting that the meningitis occurred during the seroconversion in this patient.
Gene_expression (positive) of p55 in CSF associated with meningitis and acquired immune deficiency syndrome or hiv infection
1) Confidence 0.47 Published 2009 Journal Rinsho Shinkeigaku Section Abstract Doc Link 19348174 Disease Relevance 1.46 Pain Relevance 0.08
One is the ubiquitously expressed TNF-R1 (synonyms, p55 and CD120a) and the other one is TNF-R2 known also as p75 or CD120b.
Gene_expression (expressed) of p55
2) Confidence 0.13 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727880 Disease Relevance 0.44 Pain Relevance 0.35
One is the ubiquitously expressed TNF-R1 (synonyms, p55 and CD120a) and the other one is TNF-R2 known also as p75 or CD120b.
Gene_expression (synonyms) of p55
3) Confidence 0.13 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727880 Disease Relevance 0.44 Pain Relevance 0.35
However, much less is known about plasma levels of its soluble receptors sTNF-R p55 and sTNF-R p75.
Gene_expression (levels) of p55 in plasma
4) Confidence 0.08 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687935 Disease Relevance 1.57 Pain Relevance 0.38
TNF-R p55 is expressed in most tissues, whereas expression of TNF-R p75 is highly regulated and typically found in cells of the immune system.
Gene_expression (expressed) of p55 in immune system
5) Confidence 0.08 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687935 Disease Relevance 1.32 Pain Relevance 0.31
SPINK1 N34S and P55S mutations were detected by minisequencing and confirmed by direct sequencing.
Gene_expression (detected) of P55S (P55S)
6) Confidence 0.00 Published 2005 Journal Pancreas Section Body Doc Link 15782101 Disease Relevance 0.18 Pain Relevance 0

General Comments

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