INT125804

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.93
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pth)
Anatomy Link Frequency
parathyroid 3
thyroid 2
blood 1
autonomic 1
Pth (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 26 86.00 High High
Inflammation 72 83.28 Quite High
Pain 7 81.84 Quite High
imagery 9 47.60 Quite Low
rheumatoid arthritis 15 22.08 Low Low
Crohn's disease 2 16.88 Low Low
cytokine 24 5.00 Very Low Very Low Very Low
cva 13 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 25 99.92 Very High Very High Very High
Hypercalcemia 45 99.56 Very High Very High Very High
Osteoporosis 46 96.42 Very High Very High Very High
Nutritional Deficiencies 5 96.36 Very High Very High Very High
Rickets 178 94.00 High High
Fibrosis 20 86.00 High High
Interstitial Lung Diseases 143 85.48 High High
Aging 21 85.00 Quite High
INFLAMMATION 72 83.28 Quite High
Pain 6 81.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondary hyperparathyroidism is defined as autonomic secretion of parathormon (PTH) whose 1-84 fraction level is up to 60 ng/l.
Localization (secretion) of PTH in autonomic associated with hypercalcemia
1) Confidence 0.69 Published 2004 Journal Dakar Med Section Abstract Doc Link 15782473 Disease Relevance 0.32 Pain Relevance 0
The reduction in intestinal calcium absorption associated with low levels of vitamin D triggers the release of parathyroid hormone (PTH), which stimulates the absorption of calcium through augmentation of the production of 1,25(OH)2D [2, 3].
Localization (release) of PTH in parathyroid
2) Confidence 0.60 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.16 Pain Relevance 0
The reduction in intestinal calcium absorption associated with low levels of vitamin D triggers the release of parathyroid hormone (PTH), which stimulates the absorption of calcium through augmentation of the production of 1,25(OH)2D [2, 3].
Localization (release) of parathyroid hormone in parathyroid
3) Confidence 0.60 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.16 Pain Relevance 0
In mild vitamin D deficiency, the elevation of serum PTH increases the conversion of 25(OH)D to 1,25(OH)D to compensate for the insufficient 25(OH)D available; however, elevation in PTH increases bone resorption, leading to additional bone loss [19].
Localization (elevation) of PTH associated with hypercalcemia
4) Confidence 0.56 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 1.10 Pain Relevance 0.08
These recommendations are based on the amount of vitamin D that is needed to maximally suppress PTH (1–84) secretion [22], but there is no consensus, as some investigators advocate that the 25(OH)2D level needed to maximally suppress PTH is 30 to 44 ng/mL [23].
Localization (secretion) of PTH
5) Confidence 0.52 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0 Pain Relevance 0
A number of factors influence the renal tubular reabsorption of Pi, such as dietary phosphorus content, and parathyroid hormone (PTH), growth hormone (insulin-like growth factor 1) and thyroid hormone concentrations, although these latter two hormones probably do not play a major role in the short-term control of serum Pi concentrations, but, rather, determine long-term concentrations.
Localization (reabsorption) of parathyroid hormone in thyroid
6) Confidence 0.49 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0.05 Pain Relevance 0
A number of factors influence the renal tubular reabsorption of Pi, such as dietary phosphorus content, and parathyroid hormone (PTH), growth hormone (insulin-like growth factor 1) and thyroid hormone concentrations, although these latter two hormones probably do not play a major role in the short-term control of serum Pi concentrations, but, rather, determine long-term concentrations.
Localization (reabsorption) of PTH in thyroid
7) Confidence 0.49 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0.05 Pain Relevance 0
Currently osteoporosis is viewed as a heterogeneous condition which can occur in any age of life and its etiology is attributed to various endocrine, metabolic and mechanical factors (abnormalities of parathyroid hormone and calcitonin secretion, insufficient vitamin D and calcium intake, postmenopausal hormonal condition, pregnancy, nutritional disorders, immobility and consumption of drugs such as cortisone, among others) [2].
Localization (secretion) of parathyroid hormone in parathyroid associated with congenital anomalies, nutritional deficiencies and osteoporosis
8) Confidence 0.04 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 0.98 Pain Relevance 0.13
Loss-of-function mutations in CASR impair the feedback inhibition of parathyroid hormone secretion in response to a rise in the blood calcium concentration.
Localization (secretion) of parathyroid hormone in blood
9) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2939531 Disease Relevance 1.11 Pain Relevance 0.08

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