INT125813

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.88
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (TPSD1) extracellular region (TPSD1)
Anatomy Link Frequency
mast cell 1
TPSD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 52 74.96 Quite High
Bile 7 59.44 Quite High
cytokine 20 52.56 Quite High
cINOD 3 25.00 Low Low
substance P 6 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Neuropeptide 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colitis 3 99.28 Very High Very High Very High
Inflammatory Bowel Disease 1 97.44 Very High Very High Very High
Coagulation Disorder 1 90.08 High High
Apoptosis 1 76.92 Quite High
INFLAMMATION 47 74.96 Quite High
Acid Reflux 18 71.12 Quite High
Gastroesophageal Reflux Disease 45 64.16 Quite High
Esophageal Disease 20 56.92 Quite High
Stress 20 50.00 Quite Low
Adhesions 6 34.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A similar degree of inhibition of calcium ionophore A23187 (CI) induced tryptase release was also observed with these two inhibitors.
Negative_regulation (inhibition) of tryptase
1) Confidence 0.37 Published 2004 Journal Asian Pac. J. Allergy Immunol. Section Abstract Doc Link 15783133 Disease Relevance 0 Pain Relevance 0
We have demonstrated in an animal model of colitis and a model of human chronic ulcerative colitis that PAR activation by mast cell-derived tryptase is involved in the development of colitis and that anti-PAR therapy based on inhibition of tryptase is effective for the treatment of colitis [51, 52].
Negative_regulation (inhibition) of tryptase in mast cell associated with colitis and inflammatory bowel disease
2) Confidence 0.01 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 0.88 Pain Relevance 0.09

General Comments

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