INT125844

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.45
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Arrb2) transport (Arrb2) plasma membrane (Arrb2)
nucleus (Arrb2) intracellular (Arrb2) cytoplasm (Arrb2)
Anatomy Link Frequency
hippocampus 2
Arrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 17 100.00 Very High Very High Very High
Morphine 7 99.98 Very High Very High Very High
Central grey 4 99.58 Very High Very High Very High
Hippocampus 2 98.96 Very High Very High Very High
Dopamine 1 95.16 Very High Very High Very High
opiate 1 94.64 High High
agonist 1 92.56 High High
midbrain 1 75.00 Quite High
gABA 1 71.56 Quite High
GABAergic 1 66.92 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 4 99.58 Very High Very High Very High
Targeted Disruption 2 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We identified elevated expression of the beta-arrestin 2 gene (Arrb2) in the striatum and the hippocampus of ethanol-preferring AA rats compared to their nonpreferring counterpart ANA line.
Positive_regulation (elevated) of Gene_expression (expression) of Arrb2 in hippocampus associated with hippocampus
1) Confidence 0.48 Published 2008 Journal FASEB J. Section Abstract Doc Link 18367649 Disease Relevance 0 Pain Relevance 0.22
These results suggest that induction of DOPr-mediated actions in PAG by chronic morphine requires prolonged MOPr stimulation and expression of beta-arrestin-2.
Positive_regulation (requires) of Gene_expression (expression) of beta-arrestin-2 associated with opioid receptor, central grey and morphine
2) Confidence 0.25 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15788776 Disease Relevance 0.45 Pain Relevance 1.44

General Comments

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