INT125845

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.46
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1, Arrb2) intracellular (Pag1, Arrb2) signal transduction (Arrb2)
transport (Arrb2) nucleus (Arrb2) cytoplasm (Arrb2)
Pag1 (Mus musculus)
Arrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 17 100.00 Very High Very High Very High
Morphine 7 100.00 Very High Very High Very High
Central grey 4 100.00 Very High Very High Very High
agonist 1 95.04 Very High Very High Very High
midbrain 1 75.00 Quite High
gABA 1 74.04 Quite High
GABAergic 1 69.40 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 4 100.00 Very High Very High Very High
Targeted Disruption 2 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that induction of DOPr-mediated actions in PAG by chronic morphine requires prolonged MOPr stimulation and expression of beta-arrestin-2.
Positive_regulation (induction) of PAG Positive_regulation (requires) of Gene_expression (expression) of beta-arrestin-2 associated with opioid receptor, central grey and morphine
1) Confidence 0.09 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15788776 Disease Relevance 0.46 Pain Relevance 1.48

General Comments

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