INT125857

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) kinase activity (Insrr)
signal transducer activity (Oprm1)
Insrr (Mus musculus)
Oprm1 (Mus musculus)
Insrr - S196A (1)
Pain Link Frequency Relevance Heat
opioid receptor 6 100.00 Very High Very High Very High
addiction 1 96.12 Very High Very High Very High
tolerance 9 95.52 Very High Very High Very High
Opioid 2 92.88 High High
Pain 1 92.48 High High
antagonist 2 92.32 High High
Analgesic 2 90.00 High High
Antinociceptive 1 89.84 High High
agonist 2 85.68 High High
Physical dependence 1 79.44 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 99.44 Very High Very High Very High
Pain 1 92.48 High High
Drug Dependence 1 79.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, we reported the development of a mu-opioid receptor knock-in (KI) mouse in which the mu-opioid receptor was replaced by a mutant receptor (S196A) using a homologous recombination gene-targeting strategy.
receptor (S196A) Negative_regulation (replaced) of mu-opioid receptor associated with targeted disruption and opioid receptor
1) Confidence 0.01 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15788780 Disease Relevance 0.27 Pain Relevance 1.24

General Comments

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