INT125863

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Context Info
Confidence 0.28
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.66
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CFLAR)
Anatomy Link Frequency
osteoblasts 1
CFLAR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 39 96.64 Very High Very High Very High
withdrawal 7 96.24 Very High Very High Very High
Pain 13 92.96 High High
antagonist 28 88.64 High High
cINOD 3 69.36 Quite High
dexamethasone 43 57.76 Quite High
pregabalin 1 41.08 Quite Low
Gabapentin 1 40.48 Quite Low
gABA 9 39.80 Quite Low
dorsal root ganglion 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 27 97.72 Very High Very High Very High
Pain 14 92.96 High High
Colon Cancer 5 91.44 High High
Cancer 7 82.96 Quite High
Apoptosis 114 82.72 Quite High
Necrosis 2 74.48 Quite High
Disease 2 68.84 Quite High
Bordatella Infection 1 62.12 Quite High
Death 13 5.00 Very Low Very Low Very Low
Nociception 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional intracellular factors leading to TRAIL-resistance affect the caspase 8/c-FLIP ratio, such as loss of caspase 8 and caspase 10 due to mutations or gene methylation, CARP-dependent degradation of active caspase 8 and changes in caspase 8 or c-FLIP expression levels.
Regulation (affect) of c-FLIP
1) Confidence 0.28 Published 2004 Journal Drug Resist. Updat. Section Abstract Doc Link 15790545 Disease Relevance 1.06 Pain Relevance 0.07
A FLIPR response immediately upon the addition of a test compound would indicate its activity as an agonist.
Regulation (response) of FLIPR associated with agonist
2) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2947157 Disease Relevance 0.16 Pain Relevance 0.31
Therefore, the FLIPs are highly mitogen-sensitive in osteoblasts, responding very strongly to mitogenic stimulation and more weakly to mitogen withdrawal.
Regulation (sensitive) of FLIPs in osteoblasts associated with withdrawal
3) Confidence 0.00 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.44 Pain Relevance 0.10

General Comments

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