INT125867

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 8.50
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP8) peptidase activity (CASP8) mitochondrion (CASP8)
nucleolus (CASP8) cytoskeleton (CASP8) nucleus (CASP8)
Anatomy Link Frequency
cleavage 5
macrophages 1
CASP8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 8 83.40 Quite High
COX-2 inhibitor 1 75.00 Quite High
Inflammation 21 50.00 Quite Low
midbrain 11 50.00 Quite Low
cytokine 15 5.00 Very Low Very Low Very Low
Substantia nigra 9 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 341 99.52 Very High Very High Very High
Death 75 96.84 Very High Very High Very High
Cancer 143 91.48 High High
Colon Cancer 58 89.40 High High
Lung Cancer 2 87.08 High High
Familial Adenomatous Polyposis 2 78.80 Quite High
Necrosis 14 76.48 Quite High
INFLAMMATION 21 75.28 Quite High
Disease 11 66.80 Quite High
Pox Virus Infection 57 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A pan-caspase inhibitor, z-VAD-fmk, suppressed this increase in apoptosis and also suppressed the cleavage of caspase-8, caspase-3, and PARP, suggesting a caspase-dependent mechanism.
Protein_catabolism (cleavage) of caspase-8 in cleavage associated with apoptosis
1) Confidence 0.65 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19360361 Disease Relevance 0.58 Pain Relevance 0.27
Coadministration of sulindac sulfide and the small-molecule Bcl-2 inhibitor HA14-1 increased apoptosis induction and enhanced caspase-8 and caspase-9 cleavage, Bax redistribution, and cytochrome c and second mitochondria-derived activator of caspase release.
Protein_catabolism (cleavage) of caspase-8 in cleavage associated with apoptosis
2) Confidence 0.60 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 16227396 Disease Relevance 1.36 Pain Relevance 0.14
Additional intracellular factors leading to TRAIL-resistance affect the caspase 8/c-FLIP ratio, such as loss of caspase 8 and caspase 10 due to mutations or gene methylation, CARP-dependent degradation of active caspase 8 and changes in caspase 8 or c-FLIP expression levels.
Protein_catabolism (degradation) of caspase 8
3) Confidence 0.42 Published 2004 Journal Drug Resist. Updat. Section Abstract Doc Link 15790545 Disease Relevance 1.01 Pain Relevance 0.08
The present data report that UVB irradiation induced levels of cleaved caspase-8 and -9.
Protein_catabolism (cleaved) of caspase-8
4) Confidence 0.22 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 1.13 Pain Relevance 0
Additional intracellular factors leading to TRAIL-resistance affect the caspase 8/c-FLIP ratio, such as loss of caspase 8 and caspase 10 due to mutations or gene methylation, CARP-dependent degradation of active caspase 8 and changes in caspase 8 or c-FLIP expression levels.
Protein_catabolism (degradation) of caspase 8
5) Confidence 0.18 Published 2004 Journal Drug Resist. Updat. Section Abstract Doc Link 15790545 Disease Relevance 1.05 Pain Relevance 0.08
Thus, overexpression of human and viral GAAPs provides partial protection against apoptosis triggered by the extrinsic pathway, and this inhibition takes place downstream of caspase-8 cleavage.


Protein_catabolism (cleavage) of caspase-8 in cleavage associated with apoptosis
6) Confidence 0.09 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.22 Pain Relevance 0
and CHX and examined cleavage of caspase-8.
Spec (examined) Protein_catabolism (cleavage) of caspase-8 in cleavage
7) Confidence 0.09 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.74 Pain Relevance 0
Biochemical analysis confirmed that while macrophages inhibited TRAIL-induced activation of caspase 8 and caspase-9 and cleavage of PARP and ?
Protein_catabolism (cleavage) of caspase 8 in macrophages
8) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.14 Pain Relevance 0
There was no gross difference in proteolytic cleavage of caspase-8 into its active p43/p41 and p18 fragments between both cell lines after 2, 4, and 6 h (Figure 6C).
Protein_catabolism (cleavage) of caspase-8 in cleavage
9) Confidence 0.06 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.67 Pain Relevance 0
We identified dying cells by the presence of cleaved caspase-8, cleaved caspase-3, and oligomerized BAX (Figures 4A–4F).
Protein_catabolism (cleaved) of caspase-8
10) Confidence 0.06 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525922 Disease Relevance 0.61 Pain Relevance 0

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