INT125871

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 11.46
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (XIAP) intracellular (XIAP) ligase activity (XIAP)
cytoplasm (XIAP)
XIAP (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 11 99.44 Very High Very High Very High
cINOD 6 95.04 Very High Very High Very High
agonist 34 93.44 High High
Inflammation 63 86.44 High High
qutenza 3 79.84 Quite High
COX-2 inhibitor 4 74.64 Quite High
antagonist 23 70.84 Quite High
cytokine 14 67.48 Quite High
metalloproteinase 140 5.00 Very Low Very Low Very Low
chemokine 40 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 1 100.00 Very High Very High Very High
Lung Cancer 689 99.84 Very High Very High Very High
Colon Cancer 81 99.44 Very High Very High Very High
Apoptosis 269 99.24 Very High Very High Very High
Solid Tumor 25 98.96 Very High Very High Very High
Cancer 379 86.88 High High
Pleurisy 5 86.84 High High
INFLAMMATION 63 86.44 High High
Squamous Cell Carcinoma 7 76.92 Quite High
Death 33 74.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further downstream in the TRAIL apoptotic pathway, Bax mutations, or increased expression of IAP family members, in particularly XIAP and survivin, also cause resistance.
Gene_expression (expression) of XIAP associated with apoptosis
1) Confidence 0.65 Published 2004 Journal Drug Resist. Updat. Section Abstract Doc Link 15790545 Disease Relevance 0.89 Pain Relevance 0.10
Aspirin, however, had no effect on expressions of Bcl-2, XIAP, and HIAP-1 in YD-8 cells.
Gene_expression (expressions) of XIAP associated with aspirin
2) Confidence 0.60 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.63 Pain Relevance 0.63
increased caspase-8 and -9 activity and reduced expression of XIAP and
Gene_expression (expression) of XIAP
3) Confidence 0.35 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.95 Pain Relevance 0.17
proteins Bcl-2, COX-2, and XIAP in retinoblastoma protein (RB)-deficient human
Gene_expression (deficient) of XIAP associated with retinoblastoma
4) Confidence 0.20 Published 2009 Journal PPAR Research Section Body Doc Link PMC2672162 Disease Relevance 1.13 Pain Relevance 0.37
These data suggest that XIAP and Survivin, but not Livin, are frequently expressed in MM, and that the reduced nuclear Survivin expression in effusions may be related to lesser degree of proliferation.
Neg (not) Gene_expression (expressed) of XIAP associated with lung cancer
5) Confidence 0.12 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.53 Pain Relevance 0.03
Immunohistochemical analysis of 112 MM showed significantly higher XIAP expression in peritoneal compared to pleural MM and in effusions compared to solid lesions, with reduced expression of nuclear (postulated proliferation-related) Survivin and the proliferation marker Ki-67 in effusions compared to solid tumors.
Gene_expression (expression) of XIAP associated with lung cancer and solid tumor
6) Confidence 0.12 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.56 Pain Relevance 0.04
Using immunoblotting, we detected expression of XIAP and Survivin, but no expression of Livin, in effusion specimens.
Gene_expression (expression) of XIAP
7) Confidence 0.12 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.52 Pain Relevance 0.04
Using immunoblotting, we detected expression of XIAP and Survivin, but no expression of Livin, in effusion specimens.
Neg (no) Gene_expression (expression) of XIAP
8) Confidence 0.09 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.58 Pain Relevance 0.04
We recently analyzed the expression of XIAP, Survivin and Livin in MM (Kleinberg, 2007).
Spec (analyzed) Gene_expression (expression) of XIAP associated with lung cancer
9) Confidence 0.09 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.66 Pain Relevance 0.04

General Comments

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