INT125874

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.84
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP10) peptidase activity (CASP10) plasma membrane (CASP10)
CASP10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 73.20 Quite High
Inflammation 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shigella Infection 3 93.32 High High
Apoptosis 200 92.80 High High
Colon Cancer 48 89.72 High High
Cancer 35 81.24 Quite High
Necrosis 8 72.76 Quite High
Reprotox - General 1 10 72.48 Quite High
Disease 7 67.12 Quite High
Repression 7 66.68 Quite High
Infection 26 22.64 Low Low
Stress 1 5.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional intracellular factors leading to TRAIL-resistance affect the caspase 8/c-FLIP ratio, such as loss of caspase 8 and caspase 10 due to mutations or gene methylation, CARP-dependent degradation of active caspase 8 and changes in caspase 8 or c-FLIP expression levels.
Negative_regulation (loss) of caspase 10
1) Confidence 0.41 Published 2004 Journal Drug Resist. Updat. Section Abstract Doc Link 15790545 Disease Relevance 1.05 Pain Relevance 0.07
Of the few additional changes seen, it is interesting to see that CASP10 was repressed in WTSTS cells compared to WT cells.
Negative_regulation (repressed) of CASP10
2) Confidence 0.22 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.30 Pain Relevance 0
Immunoblotting was used to validate Caspase 10 and BTG1 in order to assess whether mRNA regulation was associated with a corresponding change in protein levels.
Negative_regulation (validate) of Caspase 10
3) Confidence 0.17 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.49 Pain Relevance 0

General Comments

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