INT125877

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Context Info
Confidence 0.04
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.26
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PKLR) small molecule metabolic process (PKLR) carbohydrate metabolic process (PKLR)
PKLR (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1 96.60 Very High Very High Very High
tetrodotoxin 2 90.36 High High
Angina 1 56.56 Quite High
ischemia 1 56.12 Quite High
Disease Link Frequency Relevance Heat
Cardiovascular Disease 1 95.36 Very High Very High Very High
Cv General 3 Under Development 1 56.56 Quite High
Coronary Artery Disease 1 56.12 Quite High
Increased Venous Pressure Under Development 1 53.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data strongly suggest, for the first time, the molecular requirements for testosterone binding to L-type Ca2+ channels, thereby supporting its beneficial role as an endogenous Ca2+ channel antagonist in the treatment of cardiovascular disease.
L-type Binding (binding) of associated with cardiovascular disease and antagonist
1) Confidence 0.04 Published 2007 Journal Cell Calcium Section Abstract Doc Link 17173968 Disease Relevance 0.26 Pain Relevance 0.13
Mibefradil has a higher affinity for T-type over L-type Ca2+ channels, and the drug has been used in the gastrointestinal tract to identify T-type currents.
L-type Binding (affinity) of
2) Confidence 0.00 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15790762 Disease Relevance 0 Pain Relevance 0.09

General Comments

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