INT125884

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 23
Disease Relevance 34.04
Pain Relevance 4.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CHI3L1) extracellular region (CHI3L1) endoplasmic reticulum (CHI3L1)
proteinaceous extracellular matrix (CHI3L1) carbohydrate metabolic process (CHI3L1) cytoplasm (CHI3L1)
Anatomy Link Frequency
plasma 5
macrophages 2
joint 1
subcutaneous adipose tissue 1
heart 1
CHI3L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 27 100.00 Very High Very High Very High
rheumatoid arthritis 262 99.84 Very High Very High Very High
metalloproteinase 13 99.70 Very High Very High Very High
Arthritis 126 98.36 Very High Very High Very High
Inflammation 328 98.24 Very High Very High Very High
Chronic pancreatitis 6 97.96 Very High Very High Very High
tolerance 72 97.12 Very High Very High Very High
imagery 14 90.64 High High
cytokine 54 89.88 High High
spinal inflammation 18 78.88 Quite High
Disease Link Frequency Relevance Heat
Calcification 837 100.00 Very High Very High Very High
INFLAMMATION 350 100.00 Very High Very High Very High
Diabetes Mellitus 815 99.96 Very High Very High Very High
Rheumatoid Arthritis 266 99.84 Very High Very High Very High
Obesity 441 99.68 Very High Very High Very High
Atherosclerotic Plaque 18 99.60 Very High Very High Very High
Coronary Artery Disease 684 99.28 Very High Very High Very High
Disease 94 99.28 Very High Very High Very High
Pancreatic Cancer 5 99.28 Very High Very High Very High
Cancer 56 99.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One previous study (20) has shown an elevation of serum YKL-40 in type 2 diabetes.
Positive_regulation (elevation) of YKL-40 associated with diabetes mellitus
1) Confidence 0.62 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 2.38 Pain Relevance 0.37
Since the functional role of pDCs in disease pathogenesis is only partly understood, we also wished to address whether these cells represent a population distinct from the described nuclear RelB+ synovial DCs, and whether they may contribute as APCs or inflammatory cells in RA [21].


Positive_regulation (nuclear) of synovial associated with inflammation, rheumatoid arthritis and disease
2) Confidence 0.49 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.96 Pain Relevance 0.42
Intracellular citrullinated proteins and MHC–HC gp39 peptide complexes were not observed in PsA, whereas 44% of RA samples were positive for citrullinated proteins and 46% were positive for MHC–HC gp39 peptide complexes (for both: P = 0.001).
Positive_regulation (positive) of HC gp39 associated with rheumatoid arthritis and arthritis
3) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174942 Disease Relevance 1.58 Pain Relevance 0.82
There was no significant difference in the levels of serum HC gp-39 in patients with pancreatic cancer and those with chronic pancreatitis.
Positive_regulation (levels) of serum HC gp-39 associated with pancreatic cancer and chronic pancreatitis
4) Confidence 0.41 Published 2005 Journal Mod. Pathol. Section Abstract Doc Link 15791284 Disease Relevance 1.05 Pain Relevance 0.40
The positive correlation between subcutaneous adipose tissue YKL-40 mRNA and plasma YKL-40 support the idea that adipose tissue contributes to circulating YKL-40.
Positive_regulation (circulating) of YKL-40 in subcutaneous adipose tissue associated with obesity
5) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 1.11 Pain Relevance 0.05
Ongoing studies in our laboratory show that acute elevation of plasma IL-6 (by intravenous infusion) increase plasma YKL-40 in humans.
Positive_regulation (increase) of plasma YKL-40 in plasma
6) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 0.88 Pain Relevance 0.06
Plasma YKL-40 was increased in type 2 diabetic patients compared with subjects with normal glucose tolerance, independently of obesity (P < 0.0001).
Positive_regulation (increased) of Plasma YKL-40 in Plasma associated with diabetes mellitus, obesity, tolerance and impaired glucose tolerance
7) Confidence 0.36 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 1.28 Pain Relevance 0.14
In healthy subjects, 3 h of hyperglycemic clamp conditions or hyperinsulinemic-euglycemic clamp conditions did not change plasma YKL-40 (Fig. 2B).



Neg (not) Positive_regulation (change) of plasma YKL-40 in plasma
8) Confidence 0.36 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 0.88 Pain Relevance 0.07
In the present study, we demonstrated that patients with type 2 diabetes have elevated plasma YKL-40 compared with healthy control subjects.
Positive_regulation (elevated) of plasma YKL-40 in plasma associated with diabetes mellitus
9) Confidence 0.36 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 0.87 Pain Relevance 0.07
Plasma YKL-40

OBJECTIVE—YKL-40 is produced by macrophages, and plasma YKL-40 is elevated in patients with diseases characterized by inflammation.

Positive_regulation (elevated) of plasma YKL-40 in plasma associated with inflammation and disease
10) Confidence 0.36 Published 2008 Journal Diabetes Section Title Doc Link PMC2570404 Disease Relevance 1.27 Pain Relevance 0.16
Plasma YKL-40

OBJECTIVE—YKL-40 is produced by macrophages, and plasma YKL-40 is elevated in patients with diseases characterized by inflammation.

Positive_regulation (elevated) of plasma YKL-40 in macrophages associated with inflammation and disease
11) Confidence 0.12 Published 2008 Journal Diabetes Section Title Doc Link PMC2570404 Disease Relevance 1.27 Pain Relevance 0.16
Studies have shown, that increased levels of YKL-40 are independently associated with the presence and extent of CAD [29-32].
Positive_regulation (increased) of YKL-40 associated with coronary artery disease
12) Confidence 0.11 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 1.61 Pain Relevance 0.07
Furthermore, individuals with known chronic obstructive pulmonary disease, kidney disease or cancer were also excluded, because levels of YKL-40 are known to be increased in these conditions [14].
Positive_regulation (increased) of YKL-40 in kidney associated with pulmonary disease, cancer and renal disease
13) Confidence 0.11 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 1.84 Pain Relevance 0.08
We found significantly increased YKL-40 concentrations in patients with either T2D and/or IHD, thus confirming previous studies [27-30].
Positive_regulation (increased) of YKL-40 associated with coronary artery disease and diabetes mellitus
14) Confidence 0.11 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 1.72 Pain Relevance 0.14
On the surface, these results appear to diverge with our previous results showing that increased firing rates in CGp correlate with increased reaction times for performing a single task (Hayden et al., 2009).
Positive_regulation (increased) of CGp
15) Confidence 0.10 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3001991 Disease Relevance 0.42 Pain Relevance 0
YKL-40 induces maturation of monocytes to macrophages and is secreted by macrophages during late stages of differentiation and by activated macrophages [14,15].
Positive_regulation (induces) of YKL-40 in macrophages
16) Confidence 0.08 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 2.00 Pain Relevance 0.08
Markers like C-reactive protein (CRP), matrix metalloproteinase-3 (MMP-3) and YKL-40 have also been used for assessing the extent of synovitis in RA patients [16-19].
Positive_regulation (used) of YKL-40 associated with synovitis, rheumatoid arthritis and metalloproteinase
17) Confidence 0.08 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2426686 Disease Relevance 0.42 Pain Relevance 0.33
In patients with type 1 diabetes, increasing levels of YKL-40 are seen with increasing levels of albuminuria, suggesting that YKL-40 might be able to be used as an early marker of CVD [33].
Positive_regulation (increasing) of YKL-40 associated with cardiovascular disease, diabetes mellitus and albuminuria
18) Confidence 0.08 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 1.65 Pain Relevance 0.03
This process is paralleled by increased levels of YKL-40 and hsCRP, which most likely reflect the concomitant low grade inflammatory state in these patients



Positive_regulation (increased) of YKL-40 associated with inflammation
19) Confidence 0.08 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC3016330 Disease Relevance 2.51 Pain Relevance 0.14
Levels of MGP, YKL-40 and hsCRP were increased in patients with IHD and/or T2D (p < 0.0001) and patients with T2D and IHD had higher MGP levels (p < 0.001).
Positive_regulation (increased) of YKL-40 associated with calcification, coronary artery disease and diabetes mellitus
20) Confidence 0.08 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC3016330 Disease Relevance 2.75 Pain Relevance 0.12

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