INT125885

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 10.80
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CHI3L1) extracellular region (CHI3L1) endoplasmic reticulum (CHI3L1)
proteinaceous extracellular matrix (CHI3L1) carbohydrate metabolic process (CHI3L1) cytoplasm (CHI3L1)
Anatomy Link Frequency
cartilage 4
adipose tissue 4
monocytes 2
kidney 2
CHI3L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 219 99.84 Very High Very High Very High
Arthritis 82 98.88 Very High Very High Very High
spinal inflammation 19 98.60 Very High Very High Very High
Chronic pancreatitis 12 96.48 Very High Very High Very High
Inflammation 128 89.36 High High
chemokine 36 79.28 Quite High
cytokine 86 68.08 Quite High
Inflammatory marker 6 50.00 Quite Low
fibrosis 3 46.00 Quite Low
metalloproteinase 7 38.56 Quite Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 10 100.00 Very High Very High Very High
Obesity 111 99.88 Very High Very High Very High
Rheumatoid Arthritis 222 99.84 Very High Very High Very High
Cancer 16 99.42 Very High Very High Very High
Renal Disease 2 99.22 Very High Very High Very High
Pancreatitis 16 99.00 Very High Very High Very High
Pulmonary Disease 2 98.90 Very High Very High Very High
Seronegative Spondarthritis 17 98.88 Very High Very High Very High
Infectious Arthritis 1 98.80 Very High Very High Very High
Low Back Pain 19 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to CXCL10, synovial CXCL8 concentrations were only significantly (P < 0.05) enhanced in RA patients, and not in PsA or AS patients, in comparison with CA patients (Figure 11).
Neg (not) Positive_regulation (enhanced) of Gene_expression (concentrations) of synovial associated with spinal inflammation, rheumatoid arthritis and arthritis
1) Confidence 0.49 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 1.69 Pain Relevance 1.04
Overall, these results strongly support the notion that lymphoid structures expressing AID and CD21L can directly contribute to ACPA production within the rheumatoid synovial membrane.
Positive_regulation (contribute) of Gene_expression (production) of synovial
2) Confidence 0.45 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.52 Pain Relevance 0.23
It cannot be excluded that adipose tissue is a source of YKL-40 production, though the production of YKL-40 may be attributed to different cells.
Positive_regulation (attributed) of Gene_expression (production) of YKL-40 in adipose tissue associated with obesity
3) Confidence 0.45 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 1.12 Pain Relevance 0.03
These 20 genes included pancreatitis-associated protein (HIP/PAP), a gene known to be overexpressed in acini adjacent to infiltrating pancreatic cancer, and the gene cartilage glycoprotein-39 (HC gp-39 or TKL-40).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of cartilage glycoprotein-39 in cartilage associated with pancreatic cancer and pancreatitis
4) Confidence 0.41 Published 2005 Journal Mod. Pathol. Section Abstract Doc Link 15791284 Disease Relevance 1.20 Pain Relevance 0.46
These 20 genes included pancreatitis-associated protein (HIP/PAP), a gene known to be overexpressed in acini adjacent to infiltrating pancreatic cancer, and the gene cartilage glycoprotein-39 (HC gp-39 or TKL-40).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of HC gp-39 in cartilage associated with pancreatic cancer and pancreatitis
5) Confidence 0.41 Published 2005 Journal Mod. Pathol. Section Abstract Doc Link 15791284 Disease Relevance 1.20 Pain Relevance 0.46
It cannot be excluded that adipose tissue is a source of YKL-40 production, though the production of YKL-40 may be attributed to different cells.
Positive_regulation (source) of Gene_expression (production) of YKL-40 in adipose tissue associated with obesity
6) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 1.07 Pain Relevance 0.03
Studies have shown, that increased levels of YKL-40 are independently associated with the presence and extent of CAD [29-32].
Positive_regulation (increased) of Gene_expression (levels) of YKL-40 associated with coronary artery disease
7) Confidence 0.08 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 1.61 Pain Relevance 0.07
Furthermore, individuals with known chronic obstructive pulmonary disease, kidney disease or cancer were also excluded, because levels of YKL-40 are known to be increased in these conditions [14].
Positive_regulation (increased) of Gene_expression (levels) of YKL-40 in kidney associated with pulmonary disease, cancer and renal disease
8) Confidence 0.08 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 1.85 Pain Relevance 0.08
This is further supported by overexpression of the human cartilage glycoprotein gp39 [55], a late macrophage differentiation marker [56], in circulating monocytes and tissue macrophages.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cartilage glycoprotein gp39 in monocytes
9) Confidence 0.02 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.54 Pain Relevance 0.23

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