INT125892

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 4.28
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hspb1) cytoskeleton (Hspb1) nucleus (Hspb1)
intracellular (Hspb1) response to stress (Hspb1) cytoplasm (Hspb1)
Anatomy Link Frequency
neurons 2
macrophage 1
Hspb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Snapping jaw 7 95.96 Very High Very High Very High
dorsal root ganglion 24 89.04 High High
Inflammation 32 78.72 Quite High
Peripheral nerve injury 4 71.52 Quite High
Spinal cord 68 48.92 Quite Low
Neuropeptide 20 13.84 Low Low
Inflammatory response 24 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 22 99.00 Very High Very High Very High
Temporomandibular Joint Syndrome 7 95.96 Very High Very High Very High
Targeted Disruption 4 91.88 High High
Spinal Cord Injury 116 91.24 High High
Death 48 90.88 High High
Ganglion Cysts 28 89.04 High High
Injury 140 87.60 High High
Apoptosis 96 85.68 High High
INFLAMMATION 56 78.72 Quite High
Nervous System Injury 4 70.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the divergence in the continued expression of ATF-3, and down-regulation of Hsp-27 at later time points in the current study differs from these previous findings [49,53], and suggests that other factors are involved.
Regulation (regulation) of Hsp-27
1) Confidence 0.48 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.74 Pain Relevance 0.18
An examination of the genes involved in cell stress/neuroprotection and axonal regeneration revealed a consistent up-regulation of Atf3, but only a transient up-regulation of Hspb1 (Hsp27) in LDPT neurons post-axotomy.
Regulation (regulation) of Hspb1 in neurons associated with stress
2) Confidence 0.48 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 1.19 Pain Relevance 0.15
An examination of the genes involved in cell stress/neuroprotection and axonal regeneration revealed a consistent up-regulation of Atf3, but only a transient up-regulation of Hspb1 (Hsp27) in LDPT neurons post-axotomy.
Regulation (regulation) of Hsp27 in neurons associated with stress
3) Confidence 0.48 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 1.19 Pain Relevance 0.15
On the other hand, the macrophage-like type A-cells expressed MAPKAPK-2 immunoreactions but lacked Hsp25 immunoreactivity.
Regulation (immunoreactivity) of Hsp25 in macrophage
4) Confidence 0.26 Published 2005 Journal The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Section Abstract Doc Link 15791578 Disease Relevance 0.65 Pain Relevance 0.51
There was a lack of a significant regenerative response, with the exception of an up-regulation of Atf3 and early up-regulation of Hspb1 (Hsp27), both involved in cell stress/neuroprotection as well as axonal regeneration.
Neg (exception) Regulation (regulation) of Hsp27 associated with stress
5) Confidence 0.21 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC3001741 Disease Relevance 0.52 Pain Relevance 0

General Comments

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