INT125896

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 13.73
Pain Relevance 4.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) aging (Mmp9)
extracellular region (Mmp9) proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9)
Anatomy Link Frequency
blood 4
spinal cords 4
endothelial cells 2
sciatic nerves 2
fibroblast 2
Mmp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 186 100.00 Very High Very High Very High
ischemia 43 100.00 Very High Very High Very High
Neuritis 5 100.00 Very High Very High Very High
Sciatic nerve 1 100.00 Very High Very High Very High
Spinal cord 91 99.84 Very High Very High Very High
Demyelination 10 99.76 Very High Very High Very High
fibrosis 44 99.50 Very High Very High Very High
Inflammation 314 99.48 Very High Very High Very High
Arthritis 13 93.72 High High
cytokine 62 92.28 High High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 11 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 5 100.00 Very High Very High Very High
Urological Neuroanatomy 30 99.92 Very High Very High Very High
Demyelinating Disease 20 99.76 Very High Very High Very High
Multiple Sclerosis 397 99.68 Very High Very High Very High
Fibrosis 26 99.50 Very High Very High Very High
INFLAMMATION 341 99.48 Very High Very High Very High
Disease 133 99.28 Very High Very High Very High
Arthritis 15 99.12 Very High Very High Very High
Pulmonary Disease 113 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reduction of arthritic disease by CS plus GS is associated with a reduction of IL-1beta and MMP-9 synthesis.
Negative_regulation (reduction) of Gene_expression (synthesis) of MMP-9 associated with disease and arthritis
1) Confidence 0.43 Published 2005 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 15792947 Disease Relevance 1.11 Pain Relevance 0.32
After the 14th day when fibrosis progressed, the overall expression of the MMP-2 and MMP-9 was very low.
Negative_regulation (low) of Gene_expression (expression) of MMP-9 associated with fibrosis and metalloproteinase
2) Confidence 0.35 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.94 Pain Relevance 0.87
Further study is required to better delineate MMP-9 mRNA expression patterns in blood, including the relationship with vascular reperfusion, duration of cerebral ischemia, treatment with tPA, and correlation with expression patterns of MMP-9 in cerebral tissue.


Negative_regulation (delineate) of Gene_expression (expression) of MMP-9 in blood associated with cv general 4 under development and ischemia
3) Confidence 0.31 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.75 Pain Relevance 0.14
Further study is required to better delineate MMP-9 mRNA expression patterns in blood, including the relationship with vascular reperfusion, duration of cerebral ischemia, treatment with tPA, and correlation with expression patterns of MMP-9 in cerebral tissue.


Negative_regulation (delineate) of Gene_expression (expression) of MMP-9 in blood associated with cv general 4 under development and ischemia
4) Confidence 0.31 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 1.12 Pain Relevance 0.19
Western blot studies showed that animals stressed for 21 days after inoculation with MOG showed lower MMP-9 expression in spinal cord than animals only inoculated with MOG (figure 2A; F: 2,332, dF: 13).
Negative_regulation (lower) of Gene_expression (expression) of MMP-9 in spinal cord associated with spinal cord
5) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.05 Pain Relevance 0.13
Mechanical ventilation and MMP-9 activity
Negative_regulation (ventilation) of Gene_expression (activity) of MMP-9
6) Confidence 0.23 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2824689 Disease Relevance 0 Pain Relevance 0
Conversely, chronically stressed (21 days) EAE-induced DA rats show increased 15d-PGJ2 levels, amelioration of clinical score, and reduced myelin loss, MMP-9 expression, MPO activity, and accumulation of neuroinflammatory mediators in the spinal cords of these animals.
Negative_regulation (reduced) of Gene_expression (expression) of MMP-9 in spinal cords associated with multiple sclerosis and urological neuroanatomy
7) Confidence 0.19 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.48 Pain Relevance 0.16
At day 12, MMP-9 expression was higher in the EAE+S group compared to the EAE group (figure 5C: F:405,1, dF:7), suggesting that stress could be enhancing EAE-induced BBB dysfunction, in contrast to what was observed on day 21.
Negative_regulation (higher) of Gene_expression (expression) of MMP-9 associated with stress and multiple sclerosis
8) Confidence 0.19 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.56 Pain Relevance 0.15
The inhibitory effect of these kinase inhibitors on MMP-9 expression in BAL fluid was also observed (Figure 5C and 5Flane 3).
Negative_regulation (effect) of Gene_expression (expression) of MMP-9 associated with metalloproteinase
9) Confidence 0.18 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0 Pain Relevance 0.32
T cell, B cell, and macrophage infiltration, inflammatory demyelination, and local expression of interleukine-17 and matrix metalloproteinase-9 in sciatic nerves of EAN rats were significantly decreased by AUY954 treatment.
Negative_regulation (decreased) of Gene_expression (expression) of matrix metalloproteinase-9 in sciatic nerves associated with demyelination, inflammation, metalloproteinase, sciatic nerve and neuritis
10) Confidence 0.17 Published 2009 Journal J. Neuroimmunol. Section Abstract Doc Link 19804913 Disease Relevance 1.24 Pain Relevance 0.80
B, and AP1 by decreasing their DNAbinding leading to decreased expression of the downstream genes iNOS, MMP9, and
Negative_regulation (decreased) of Gene_expression (expression) of MMP9
11) Confidence 0.15 Published 2008 Journal PPAR Research Section Body Doc Link PMC2293414 Disease Relevance 1.82 Pain Relevance 0.47
Inhibition of synthesis of MMP-8 and MMP-9 by endothelial cells in response to doxycycline and to a lesser extent by the chemically modified tetracyclines (CMTs) has been demonstrated at the mRNA level [56].
Negative_regulation (Inhibition) of Gene_expression (synthesis) of MMP-9 in endothelial cells
12) Confidence 0.08 Published 2008 Journal The Open Dentistry Journal Section Body Doc Link PMC2581528 Disease Relevance 0.96 Pain Relevance 0.27
decreases MMP-9 expression and its activity [88-91].
Negative_regulation (decreases) of Gene_expression (expression) of MMP-9
13) Confidence 0.05 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0 Pain Relevance 0.05
SB 239063, a small- molecule p38 inhibitor, attenuated neutrophil infiltration induced by inhaled LPS and decreased IL-6 and MMP-9 levels in rat BALF (Underwood et al 2000), thus being possibly useful for COPD treatment.
Negative_regulation (decreased) of Gene_expression (levels) of MMP-9 in neutrophil associated with pulmonary disease
14) Confidence 0.04 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.39 Pain Relevance 0.14
In the latter case, eg, Mohan et al showed that curcuminoids target fibroblast growth factor-2 and inhibit expression of gelatinase B in the angiogenic process by using the cultured corneal cells of a transgenic mouse.9 In an experimental dry eye model, Chen et al investigated the anti-inflammatory effects of curcumin in curcumin pretreated cultured corneal epithelial cells exposed to hyperosmotic conditions. 29 Kumar et al30 reported that curcumin feeding to rats with chemical-induced hyperglycemia can reduce oxidative stress that is the main cause of progression of cataract.1–12 The beneficial effects of this drug appear now to be related to the effect on upregulation of peroxisome proliferator-activated receptor-?
Negative_regulation (inhibit) of Gene_expression (expression) of gelatinase B in fibroblast associated with stress, hyperglycemia, targeted disruption, inflammation, dry eye and cataract
15) Confidence 0.03 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2964958 Disease Relevance 1.32 Pain Relevance 0.18

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