INT125897

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.36
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) aging (Mmp9)
extracellular region (Mmp9) proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9)
Anatomy Link Frequency
joint 1
nerve 1
Mmp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 5 99.76 Very High Very High Very High
Pain 24 98.84 Very High Very High Very High
Inflammatory mediators 1 92.56 High High
metalloproteinase 10 92.48 High High
COX2 1 90.72 High High
Neurotransmitter 2 87.84 High High
cytokine 9 86.92 High High
Inflammation 34 82.16 Quite High
Hyperalgesia 43 81.04 Quite High
nociceptor 4 77.60 Quite High
Disease Link Frequency Relevance Heat
Arthritis 6 99.76 Very High Very High Very High
Pressure And Volume Under Development 4 99.24 Very High Very High Very High
Pain 36 98.84 Very High Very High Very High
Nervous System Injury 2 98.28 Very High Very High Very High
Disease 6 93.24 High High
INFLAMMATION 36 92.56 High High
Lung Injury 38 91.36 High High
Tendinopathy 7 84.28 Quite High
Hyperalgesia 43 81.04 Quite High
Nociception 10 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with CS alone and CS plus GS inhibited the production of edema and prevented raised levels of joint MMP-9 associated with arthritis.
MMP-9 Binding (associated) of in joint associated with pressure and volume under development and arthritis
1) Confidence 0.36 Published 2005 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 15792947 Disease Relevance 1.14 Pain Relevance 0.39
Identified proteins could be a proteolytic target for MMP-9 and therefore the use of doxycycline as MMP-9 inhibitor could prevent their degradation during high tidal volume ventilation.
MMP-9 Binding (target) of
2) Confidence 0.22 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2824689 Disease Relevance 0.40 Pain Relevance 0
For example, MMP9 that shows increased expression in ruptured tendon has been associated with microglial activation and pain after nerve injury in animal models [38].
MMP9 Binding (associated) of in nerve associated with pain and nervous system injury
3) Confidence 0.19 Published 2010 Journal Mol Pain Section Body Doc Link PMC2914030 Disease Relevance 0.83 Pain Relevance 0.92

General Comments

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