INT125902

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Context Info
Confidence 0.51
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.13
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Cldn5) plasma membrane (Cldn5)
Anatomy Link Frequency
ileum 2
brain 2
Cldn5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 28 96.92 Very High Very High Very High
IPN 21 96.32 Very High Very High Very High
Hyperalgesia 4 87.48 High High
Inflammation 12 86.80 High High
anesthesia 3 82.44 Quite High
withdrawal 1 73.00 Quite High
Multiple sclerosis 2 67.96 Quite High
halothane 1 67.44 Quite High
Central nervous system 1 47.76 Quite Low
Pain 10 25.00 Low Low
Disease Link Frequency Relevance Heat
Reperfusion Injury 21 97.68 Very High Very High Very High
Cv Unclassified Under Development 24 96.92 Very High Very High Very High
Inflammatory Pain 21 93.76 High High
Adhesions 2 92.64 High High
Hyperalgesia 4 87.48 High High
INFLAMMATION 2 86.80 High High
Pressure And Volume Under Development 2 75.00 Quite High
Demyelinating Disease 2 67.96 Quite High
Stroke 2 66.64 Quite High
Disease 3 64.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased claudin-5 expression was not limited to the junction.
Positive_regulation (increased) of Gene_expression (expression) of claudin-5
1) Confidence 0.51 Published 2006 Journal Brain Res. Section Abstract Doc Link 17007822 Disease Relevance 0.75 Pain Relevance 0.49
Analysis of the TJ proteins, which control the paracellular pathway, demonstrated decreased claudin-5 expression at 24 h, and an increase at 48 and 72 h post-injection.
Positive_regulation (increase) of Gene_expression (expression) of claudin-5
2) Confidence 0.32 Published 2006 Journal Brain Res. Section Abstract Doc Link 17007822 Disease Relevance 0.96 Pain Relevance 0.66
Pharmacological inhibition of ALK5 with the selective inhibitor SB431542 further enhanced brain uptake of (14)C-sucrose, increased TJ protein expression (i.e., claudin-3, claudin-5, occludin, ZO-1), and decreased nuclear expression of TGF-beta/ALK5 signaling molecules (i.e., Smad2, Smad3), which suggests a role for TGF-beta/ALK5 signaling in the regulation of BBB integrity.
Positive_regulation (increased) of Gene_expression (expression) of claudin-5 in brain
3) Confidence 0.21 Published 2009 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 19319146 Disease Relevance 0.14 Pain Relevance 0.14
Expression of the transmembrane TJ proteins occludin and claudin-3 and -5 significantly changed with CFA treatment with a 60% decrease in occludin, a 450% increase in claudin-3, and a 615% increase in claudin-5 expression.
Positive_regulation (increase) of Gene_expression (expression) of claudin-5
4) Confidence 0.18 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15792985 Disease Relevance 0.60 Pain Relevance 0.72
Immunohistochemistry using control sections of rat ileum demonstrated the expression of claudin-1, claudin-2, claudin-3, claudin-4, claudin-5, ZO-1, and occludin.
Positive_regulation (demonstrated) of Gene_expression (expression) of claudin-5 in ileum
5) Confidence 0.08 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.68 Pain Relevance 0.15

General Comments

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