INT125904

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.06
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ocln) plasma membrane (Ocln) cytoplasm (Ocln)
Anatomy Link Frequency
brain 2
Ocln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 27 99.86 Very High Very High Very High
ischemia 14 98.44 Very High Very High Very High
IPN 7 91.68 High High
anesthesia 7 84.48 Quite High
Hyperalgesia 2 78.12 Quite High
withdrawal 3 75.04 Quite High
halothane 1 69.48 Quite High
Central nervous system 5 49.80 Quite Low
imagery 5 39.60 Quite Low
Inflammation 15 25.00 Low Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 7 98.44 Very High Very High Very High
Diabetes Mellitus 90 92.80 High High
Sepsis 40 80.48 Quite High
Hyperalgesia 2 78.12 Quite High
Pressure And Volume Under Development 15 77.04 Quite High
Inflammatory Pain 7 75.00 Quite High
Diabetic Retinopathy 5 73.76 Quite High
Heart Rate Under Development 4 73.12 Quite High
Brain Hemorrhage 22 68.32 Quite High
Hematoma 4 62.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of the transmembrane TJ proteins occludin and claudin-3 and -5 significantly changed with CFA treatment with a 60% decrease in occludin, a 450% increase in claudin-3, and a 615% increase in claudin-5 expression.
Positive_regulation (increase) of occludin
1) Confidence 0.45 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15792985 Disease Relevance 0.62 Pain Relevance 0.73
In the current study, MMP-9 was increased in microvessel preparation along with decreased occludin.
Positive_regulation (increased) of occludin associated with metalloproteinase
2) Confidence 0.27 Published 2010 Journal Diabetes Section Body Doc Link PMC2797926 Disease Relevance 1.01 Pain Relevance 0.19
Western blot analysis with brain tissue homogenates show that the protein levels of the tight junction proteins ZO-1 and occludin in the ultrasound treated region is not changed compared to non-treated regions (Figure 3A).
Neg (not) Positive_regulation (changed) of occludin in brain
3) Confidence 0.22 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
After a 5 day culture period, cells were either lysed for western analysis of tight junction protein expressin (claudin 3, 4, 5, 7, 8, and 18, occludin, ZO-1, and JAM-A) and MAPk (JNK, ERK, an p38) signaling activation, or barrier function was examined by measuring transepithelial resistance (TER) or the flux of two molecular tracers (5 and 20 Å).
Positive_regulation (activation) of occludin
4) Confidence 0.18 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2892473 Disease Relevance 0.22 Pain Relevance 0
We probed these lysates for JAM-A, claudin 4, claudin 18, and occludin (Figure 11).
Positive_regulation (lysates) of occludin
5) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0.07 Pain Relevance 0
Pharmacological inhibition of ALK5 with the selective inhibitor SB431542 further enhanced brain uptake of (14)C-sucrose, increased TJ protein expression (i.e., claudin-3, claudin-5, occludin, ZO-1), and decreased nuclear expression of TGF-beta/ALK5 signaling molecules (i.e., Smad2, Smad3), which suggests a role for TGF-beta/ALK5 signaling in the regulation of BBB integrity.
Positive_regulation (increased) of occludin in brain
6) Confidence 0.09 Published 2009 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 19319146 Disease Relevance 0.14 Pain Relevance 0.14

General Comments

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