INT12595

Context Info Confidence 0.70 First Reported 1983 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 14 Total Number 15 Disease Relevance 4.92 Pain Relevance 3.47

extracellular space (LPO) oxidoreductase activity (LPO) extracellular region (LPO) cellular_component (LPO)

Anatomy Link Frequency macrophages 1 plasma 1 lymphocytes 1 limbs 1 LPO (Homo sapiens)

Pain Link Frequency Relevance Heat Chronic pancreatitis 3 99.80 Pain 21 99.76 Potency 15 99.54 Paracetamol 19 98.24 Angina 4 95.82 Inflammation 20 89.28 addiction 1 84.84 ischemia 1 71.92 Bile 4 42.80 Sciatica 3 25.00

Disease Link Frequency Relevance Heat Apoptosis 16 100.00 Hepatotoxicity 13 99.80 Pancreatitis 3 99.80 Necrosis 11 99.06 Cancer 7 98.88 Syndrome 3 98.48 Pain 3 98.12 Nociception 9 96.56 Cv General 3 Under Development 4 95.82 Toxicity 72 94.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

LPO activation was also observed in experiments on animals exposed to painful tourniquetting of the limbs.

Positive_regulation (activation) of LPO in limbs associated with pain

1) Confidence 0.70 Published 1991 Journal Zh Nevropatol Psikhiatr Im S S Korsakova Section Abstract Doc Link 1666710 Disease Relevance 0.43 Pain Relevance 0.41

Examination of the patients in the exacerbation phase of chronic pancreatitis revealed activation of LPO processes and differently-directed shifts of AOP components.

Positive_regulation (activation) of LPO associated with chronic pancreatitis

2) Confidence 0.67 Published 2009 Journal Vopr Kurortol Fizioter Lech Fiz Kult Section Abstract Doc Link 19284112 Disease Relevance 0.26 Pain Relevance 0.31

Induction of microsomal enzymes enhanced LPO, inhibition of the monooxygenase systems totally suppressed it.

Positive_regulation (enhanced) of LPO

3) Confidence 0.49 Published 1983 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 6678834 Disease Relevance 0.30 Pain Relevance 0.24

The level of induced LPO was measured by the thiobarbituric acid assay, UDSox and UDSmut were determined by scintillometric measurement of incorporated [methyl-3H]thymidine into damaged DNA.

Positive_regulation (induced) of LPO

4) Confidence 0.47 Published 1990 Journal Mutat. Res. Section Abstract Doc Link 2366816 Disease Relevance 0 Pain Relevance 0.42

Unscheduled DNA synthesis (UDSox) and lipid peroxidation (LPO) induced by non-enzymatic activation of molecular oxygen (Fe2+ +H2O2) were measured in human peripheral lymphocytes from healthy volunteers.

Positive_regulation (induced) of LPO in lymphocytes

5) Confidence 0.47 Published 1990 Journal Mutat. Res. Section Abstract Doc Link 2366816 Disease Relevance 0 Pain Relevance 0.31

Investigations carried out in patients belonging to different nosological groups, differing in the intensity of pain, established the presence of a direct relationship between the potency of painful action and LPO activation.

Positive_regulation (activation) of LPO associated with pain and potency

6) Confidence 0.47 Published 1991 Journal Zh Nevropatol Psikhiatr Im S S Korsakova Section Abstract Doc Link 1666710 Disease Relevance 0.43 Pain Relevance 0.41

This may be confirmed by the circumstance that reflexotherapy determined remarkable LPO activation together with removal of the painful syndrome.

Spec (determined) Positive_regulation (activation) of LPO associated with pain and syndrome

7) Confidence 0.47 Published 1991 Journal Zh Nevropatol Psikhiatr Im S S Korsakova Section Abstract Doc Link 1666710 Disease Relevance 0.50 Pain Relevance 0.40

The results: (1) the marked effective and total effective rate in allevating AP was 75.68% and 91.89% in HT respectively; (2) activities of serum SOD and whole blood GSH-Px in HT significantly elevated than that pretreatmentally (P < 0.01); (3) comparing with CG, SOD activity and GSH-Px/LPO ratio increased (P < 0.01 and P < 0.05), whereas plasma LPO content lowered (P < 0.05).

Positive_regulation (increased) of LPO in plasma associated with angina

8) Confidence 0.45 Published 1996 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Abstract Doc Link 9206240 Disease Relevance 0.50 Pain Relevance 0.38

PC at concentrations lower than 1 mmole/l significantly potentiates the non-enzymatically induced LPO and UDSox with the maximum of the activation being around 0.1 mmole/l.

Positive_regulation (induced) of LPO associated with paracetamol

9) Confidence 0.44 Published 1990 Journal Mutat. Res. Section Abstract Doc Link 2366816 Disease Relevance 0 Pain Relevance 0.43

LPO activation did not take place in patients without changes in the clinical symptoms.

Positive_regulation (activation) of LPO

10) Confidence 0.40 Published 1991 Journal Zh Nevropatol Psikhiatr Im S S Korsakova Section Abstract Doc Link 1650091 Disease Relevance 0.23 Pain Relevance 0.04

An increased level of LPO, therefore, may affect membrane structure by altering fluidity of the membrane.

Positive_regulation (increased) of LPO

11) Confidence 0.40 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297497 Disease Relevance 0.36 Pain Relevance 0

Interestingly, the enhanced activity of LPO observed in the baseline data has been considerably reduced following administration of the potentized homeopathic drug, which is a significant finding.

Positive_regulation (enhanced) of LPO

12) Confidence 0.29 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297497 Disease Relevance 0.42 Pain Relevance 0

Concomitantly, the LPO activity also decreased with an increase in the GSH levels in the subjects (Fig. 3e and f).

Positive_regulation (increase) of LPO

13) Confidence 0.27 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297497 Disease Relevance 0.26 Pain Relevance 0

Extensive toxicological studies have now established that increase in LPO, AlkP and AcP activities along with a decrease in GSH levels denote cytotoxicity and hepatocellular dysfunctions associated with As toxicity (29–31).

Positive_regulation (increase) of LPO associated with toxicity

14) Confidence 0.23 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297497 Disease Relevance 0.32 Pain Relevance 0

Moreover, an earlier study from this laboratory determined that a 3-day treatment of hamsters with TAU was able to reduce the number of proinflammatory leukocytes, the expression of tumor necrosis factor receptor 1 (TNFR1) on macrophages, the activation of caspase-3 activity and accompanying apoptosis, LPO and the decreases in GSH and activities of antioxidant enzymes in bronchoalveolar lavage fluid (BALF) samples as a result of a challenge with LPS [31].

Positive_regulation (activation) of LPO in macrophages associated with necrosis, cancer and apoptosis

15) Confidence 0.07 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994390 Disease Relevance 0.89 Pain Relevance 0.11

General Comments

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